重庆医学Issue(1)：40-41,46,3.DOI:10.3969/j.issn.1671-8348.2016.01.014
阿奇霉素对气管导管内流感嗜血杆菌生物被膜的影响
Effects of azithromycin on the formation of nontypeable haemophilus influenzae biofilm on endotracheal tubes
王瑛 1王东 2郭治 1石书梅1
作者信息
- 1. 中国人民解放军济南军区总医院呼吸科，济南 250033
- 2. 中国人民解放军空军总医院呼吸科，北京 100083
- 折叠
摘要
Abstract
Objective To observe the formation of biofilms on endotracheal tubes ,and to determine the effect of azithromycin on Haemophilus influenzae in biofilms .Methods One hundred and twenty Wistar rats were intubated with a silicone tube ,80 of them(40 rats were model group and 40 were medicine group) were infected by bacteria to establish the animal models of endotra-cheal tube infections the others were ues as control gruop .Formation of biofilms was detected by scanning electron microscope .Via-ble cells counting was carried out to evaluate the effect of azithromycin orally on biofilms on endotracheal tubes .Results Uneven biofilms were formed on the surface of endotracheal tubes ,and slim bodied of bacteria enclosed by a lot of extracellular matrix .Via-ble cells counting was reduced in medicine group compared with model group .Conclusion Haemophilus influenzae can form bio-films on endotracheal tubes .Azithromycin can exert inhibitory effect on haemophilus influenzae biofilms formed on endotracheal tubes .关键词
插管法 ,气管内/生物被膜/阿奇霉素Key words
intubation ,ilntratracheal/biofilms/azithromycin分类
医药卫生引用本文复制引用
王瑛,王东,郭治,石书梅..阿奇霉素对气管导管内流感嗜血杆菌生物被膜的影响[J].重庆医学,2016,(1):40-41,46,3.
