重庆医学Issue(2)：202-204,3.DOI:10.3969/j.issn.1671-8348.2016.02.018
检测 ROC1在卵巢恶性上皮性肿瘤组织中的表达及临床意义研究
Expression and clinical significance of ROC1 in women with epithelial ovarian cancer
摘要
Abstract
Objective To investigate the expression and clinical significance of ROC1 in ovarian cancer tissues ,to provide new ideas for the gene therapy of ovarian cancer .Methods 261 women with ovarian cancer underwent resection from December 2005 to December 2007 in the Affiliated Hospital of Zunyi Medical College and with 5 years follow-up were enrolled .ROC1 mRNA transcription and protein expression level of ovarian cancer tissue and surrounding normal tissue were tested ,and later the correla-tion between the results and patient′s prognosis was statistically analyzed .Results ROC1 in ovarian cancer tissue was over-ex-pressed ,but almost no expression in surrounding normal ovarian carcinoma ;ROC1 expression levels had a negative correlation with the survival rate of the patients .Conclusion ROC1 in ovarian cancer tissue was over-expressed ,but almost no expression in sur-rounding normal ovarian carcinoma ;ROC1 expression levels had a negative correlation with the survival rate of the patients .关键词
ROC1/卵巢肿瘤/基因疗法/预后 ,存活率Key words
ROC1/ovarian neoplasms/gene therapy/prognosis ,survival rate分类
医药卫生引用本文复制引用
李娜,孙丽君,李东林,刘颂,高家志..检测 ROC1在卵巢恶性上皮性肿瘤组织中的表达及临床意义研究[J].重庆医学,2016,(2):202-204,3.基金项目
贵州省科技厅联合基金资助项目（黔科合J字LKZ[2012]50号）。 （）
