重庆医学Issue(3)：296-298,3.DOI:10.3969/j.issn.1671-8348.2016.03.003
大鼠伏核微量注射天麻素对神经病理性痛镇痛作用的研究
Involvement of gastrodin in antinociception in nucleus accumbens of rats with sciatic neuropathy
摘要
Abstract
Objective To determine the antinociceptive role of gastrodin in nucleus accumbens (NAc)of rats with neuropath‐ic pain .Methods The left sciatic nerve of rat was ligated to mimic neuropathic pain model ,after which the present study observed the effect of intra‐NAc injection of gastrodin on the hindpaw withdrawal latency (HWL)to noxious thermal and mechanical stimula‐tion .Results The HWL in response to thermal and mechanical stimulation significantly decreased in bilateral hindpaws in the 10th day after left sciatic nerve ligation(thermal stimulation:tleft =7 .35 ,P<0 .01;tright = 3 .24 ,P<0 .05;mechanical stimulation:tleft =5 .50 ,P<0 .01 ;tright =3 .32 ,P<0 .05) .Intra‐NAc injection of 40 or 20 μg/μL ,but not 10 μg/μL of gastrodin markedly induced an increase in the HWL in rats with neuropathic pain .Conclusion Gastrodin contributes an important antinociceptive role to neuro‐pathic pain in NAc of rats with mononeuropathy .关键词
天麻甙/疼痛/神经节/伏核/后爪缩爪潜伏期/神经病理性痛/镇痛作用Key words
gastrodin/pain/ganglia/nucleus accumbens/hindpaw withdrawal latencies/neuropathic pain/antinociceptive role分类
医药卫生引用本文复制引用
赵敏,李崇阳,李新海,钱冉,李杨,杨扬,徐世莲..大鼠伏核微量注射天麻素对神经病理性痛镇痛作用的研究[J].重庆医学,2016,(3):296-298,3.基金项目
国家自然科学基金资助项目（31360245）；云南省应用基础研究计划项目基金（2011FZ111）；云南省科技厅-昆明医科大学应用基础研究联合资金项目（2015FB012）。 （）
