重庆医学Issue(3)：307-309,3.DOI:10.3969/j.issn.1671-8348.2016.03.006
非小细胞肺癌组织中VEGF和Bax的表达及意义
Expression and significance of VEGF and Bax in non-small cell lung cancer
曹文荣 1闫文修 1王雪利1
作者信息
- 1. 山东省青岛市第八人民医院病理科 266100
- 折叠
摘要
Abstract
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and Bax in non‐small cell lung cancer (NSCLC) and clinical value .Methods Paraffin specimens were collected from 80 cases of NSCLC tissues(NSCLC group) and 20 cases of normal lung tissue adjacent to benign lesions(control group) .Western blot and immunohistochemistry were used to dectect the expression of VEGF and Bax .The relationship of the expression of VEGF and Bax with histological classifica‐tion ,stage ,lymph mode metastasis were analyzed .Results The expression of VEGF in NSCLC group was higher than that in con‐trol group ,the differences were statistically significant (P<0 .05) .The higher expression of VEGF in the group of stage Ⅲ‐Ⅳ was obtained than that in the group of stage Ⅰ‐Ⅱ (P<0 .05) .The higher expression of VEGF in the group with lymph mode metasta‐sis was obtained than that in the group without lymph mode metastasis (P<0 .05) .The expression of VEGF was not found to be related with histological classification (P>0 .05) .The expression of Bax in NSCLC tissue was lower than that in normal tissue ,the differences was statistically significant (P<0 .05) .The lower expression of Bax in the group of stage Ⅲ‐Ⅳ was obtained than that in the group of stage Ⅰ‐Ⅱ (P<0 .05) .The lower expression of Bax in the group with lymph mode metastasis was obtained than that in the group without lymph mode metastasis (P<0 .05) .The expression of Bax was not found to be related with histological classification (P>0 .05) .The expression of VEGF was negatively correlated with Bax in NSCLC (P<0 .05) .Conclusion The ex‐pression of VEGF played a promoting effect in the NSCLC ,and was negatively correlated with the expression of Bax protein ,and the expression of the two could provide a basis for the diagnosis and prognosis of NSCLC .关键词
癌 ,非小细胞肺/淋巴转移/血管内皮生长因子A/bcl-2相关X蛋白质Key words
carcinoma ,non-small-cell lung/lymphatic metastasis/vascular endothelial grow th factor A/bcl-2-associated X protein分类
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曹文荣,闫文修,王雪利..非小细胞肺癌组织中VEGF和Bax的表达及意义[J].重庆医学,2016,(3):307-309,3.
