重庆医学Issue(3)：326-328,3.DOI:10.3969/j.issn.1671-8348.2016.03.012
肉桂醛对烟曲霉菌体外生物膜的影响
Effects of cinnamaldehyde on aspergillus fumigatus biofilm in vitro
摘要
Abstract
Objective To study the treatment effect of cinnamaldehyde on Aspergillus fumigatus biofilm(BF) in vitro .Meth‐ods The models of A .fumigatus BF were established in vitro ;the minimum inhibitory concentration(MIC) on A .fumigatus was measured .The crystal violet assay and scanning electron microscopy were employed to determined the treatment effect of A .fumiga‐tus biofilm under varying concentrations of cinnamaldehyde .Results BF models were established successfully in vitro .MIC value of A .fumigatus of cinnamaldehyde was 256 μg/mL ;The biofilm biomass in serially increasing concentrations of cinnamaldehyde(1 MIC ,1/2 MIC ,1/4 MIC)were 0 .81 ± 0 .11 ,1 .13 ± 0 .18 and 1 .59 ± 0 .11 respectively .Compared to untreated control group(2 .18 ± 0 .15) ,difference achieved statistical significance(P<0 .05) .SEM studies revealed the deformity of three‐dimensional structures of biofilms treated with sub‐MICs of cinnamaldehyde .Conclusion Cinnamaldehyde has significant antifungal activity against Aspergil‐lus fumigatus ,sub‐MICs could disrupt the mature biofilm in vitro .关键词
肉桂/烟曲霉菌 ,烟/生物膜/肉桂醛Key words
cinnamomum cassia/aspergillus fumigatus/biofilm/cinnamaldehyde分类
医药卫生引用本文复制引用
邬丽红,陈一强,孔晋亮,罗劲,黄宏,侯长春..肉桂醛对烟曲霉菌体外生物膜的影响[J].重庆医学,2016,(3):326-328,3.基金项目
国家自然科学基金项目（81260002）。 （）
