重庆医学Issue(3)：329-331,335,4.DOI:10.3969/j.issn.1671-8348.2016.03.013
降浊颗粒对慢性肾衰大鼠肠道Ig A的改善作用研究
The influence of Turbidity-reducing Granule on the intestinal immune function of rats with chronic renal failure
摘要
Abstract
Objective To establish a rat model of chronic renal failure (CRF) by using 5/6 subtotal nephrectomy method , then observe and evaluate the effect of Turbidity‐reducing Granule on the intestinal immune function of rats with CRF .Methods CRF model Wistar rats were divided into high ,medium and low dose group ,sham operation group ,and model control group .respec‐tively given Turbidity‐reducing Granule 4 .05 ,8 .10 ,16 .20 g · kg -1 · d-1 .Benazepril group was given 2 mL/d (1 .2 mg/d) Benaze‐pril suspension fed;model control group and the sham group are saline 2 mL/d orally .The rats were observed before and after treat‐ment of signs and general condition ,serum BUN ,Scr changes ,and pathological changes were observed under microscope .ELISA method were used to detect serum and intestinal SIgA .Results Turbidity‐reducing Granule reduced the level of serum BUN ,Scr in rats with CRF ,there were statistically significant differences of Benazepril group and high ,medium ,low dose of Turbidity‐reducing Granule group compared with model group(P<0 .05) .Compared with the model group ,the intestinal SIgA of Benazepril group and low ,middle ,high dose of group increased significantly(P<0 .05);intestinal SIgA in ,middle and high dose group were significantly increased compared with Benazepril group(P<0 .05) .Conclusion Turbidity‐reducing Granule could improve renal function and in‐testinal immune function .关键词
肾功能衰竭 ,慢性/中药疗法/降浊颗粒/肠道免疫功能Key words
kidney failure ,chronic/drug therapy(TCD)/Turbidity-reducing Granule/intestinal IgA分类
医药卫生引用本文复制引用
王坚,王清,吉勤..降浊颗粒对慢性肾衰大鼠肠道Ig A的改善作用研究[J].重庆医学,2016,(3):329-331,335,4.基金项目
2013年云南省自然科学基金（2011FZ258）。 （）
