重庆医学Issue(3)：383-386,4.DOI:10.3969/j.issn.1671-8348.2016.03.030
PTEN蛋白表达与乳腺癌患者临床病理学特征相关性的 Meta分析
Clinicopathological significance of PTEN protein expression in breast cancer:a Meta-analysis
摘要
Abstract
Objective To evaluate the association between the expression of PTEN protein and the clinicopathological char‐acteristics of breast cancer patients .Methods All eligible studies regarding the association of PTEN protein expression with clini‐copathological features in patients with breast cancer were retrieved from PubMed ,Embase ,Cochrane Library ,CNKI and Wanfang databases .Odds ratio(OR) with corresponding 95% confidence interval(95% CI) form eligible studies were pooled .Heterogeneity and publication bias were also evaluated .All analyses were operated using RevMan 5 .2 software .Results A total of 28 articles con‐taining 3 172 patients were ultimately included for this Meta‐analysis .Our findings revealed that the expression level of PTEN was significantly correlated with estrogen receptor status(OR= 3 .16 ,95% CI:2 .01 -4 .97 ,P< 0 .01) ,progesterone receptor status (OR=2 .27 ,95% CI:1 .70 -3 .04 ,P<0 .01) ,lymph node metastasis(OR=0 .36 ,95% CI :0 .27 -0 .49 ,P<0 .01) ,clinical stage (OR=2 .59 ,95% CI:2 .04-3 .30 ,P<0 .01) and histological grade(OR=2 .19 ,95% CI:1 .74-2 .75 ,P<0 .01) .Conclusion Aber‐rant PTEN expression might have strong impacts on carcinogenesis ,tumor progression ,invasion and prognosis ,which makes it a potential biomarker for early cancer screening and endocrine therapy in breast cancer .关键词
乳腺肿瘤/肿瘤抑制蛋白质类/PTEN/雌激素受体/临床病理学特征/Meta分析Key words
breast neoplasms/tumor suppressor proteins/PTEN/estrogen receptor/clinicopathological features/Meta-analy-sis分类
医药卫生引用本文复制引用
方程,龙行华..PTEN蛋白表达与乳腺癌患者临床病理学特征相关性的 Meta分析[J].重庆医学,2016,(3):383-386,4.基金项目
国家自然科学基金资助项目（30873044、81272372）；教育部留学回国人员科研启动基金资助项目（教外司留［2011］1139号）。 （）
