动物医学进展Issue(2)：80-84,5.
应用分子靶点药物治疗犬肥大细胞瘤的研究进展
Progress on Application of Molecular Target Drugs in Treatments of Canine Mast Cell Tumors
摘要
Abstract
Mast cell tumors (MCT)have the high metastatic and mortality rate.Moreover,the convention-al chemotherapy drugs have many unpleasant side effects.As such,dogs with anaplastic MCT remain a frustrating undertaking of survival time and quality of life.Therefore,it is necessary to have better under-standing of novel,effective drugs for control of MCT.With the dramatically development of molecule biol-ogy in oncology field,molecular target drugs have been aroused general concern because of their great effect and low side-effect.Especially,molecular target drugs have attained remarkably effect of canine MCT treatment.In the present paper,we emphasized the mechanism and effect of three drugs (Imatinib, Toceranib and Masitinib)which are the most commonly used in America and Europe and targeted to the c-kit gene.At last we showed the drug resistance and preventive measure caused by second mutation of c-kit gene.We hope these could provide references to scientific researchers and small animal clinical practitioners in China.关键词
犬/肥大细胞瘤/分子靶点药物/c-kit基因Key words
canine/mast cell tumor/molecular target drug/c-kit gene分类
农业科技引用本文复制引用
李格宾,杨紫嫣,林珈好,夏兆飞..应用分子靶点药物治疗犬肥大细胞瘤的研究进展[J].动物医学进展,2016,(2):80-84,5.基金项目
中央高校基本科研业务费专项资金(2015 QC011) （2015 QC011）
