动物营养学报Issue(1)：43-49,7.DOI:10.3969/j.issn.1006-267x.2016.01.007
Toll样受体及其对肠黏膜免疫的调节作用
Toll-Like Receptors and Their Regulation Role of Intestinal Mucosal Immunity
摘要
Abstract
Toll-like receptors ( TLRs) are a highly conservative group of pattern recognition receptors, which play roles of pathogen sensors in vertebrate and invertebrate species.Recently, Toll-like receptors have been far and wide concerned.The recognition of TLRs to specific ligands is the basis of the innate immune system, and it enables protective responses to mount rapidly, then, it can activate adaptive immunity against invading patho-gens.TLRs play an important role in the process of distinguishing between the pathogenic bacteria and probiotic for the intestinal immune, while secretion of antimicrobial peptides is also regulated by TLRs in intestinal epi-thelial.This paper introduced the types of TLRs, ligands and the corresponding signal pathway, and discussed the key role of TLRs in intestinal immune regulation.关键词
Toll样受体/肠黏膜免疫/配体/信号转导/抗菌肽Key words
Toll-like receptors/intestinal mucosa immune/ligands/signal transduction/antimicrobial pep-tides分类
农业科技引用本文复制引用
全佳慧,姜宁,张爱忠,黄福佳,姜殿慧,宋磊,张伟庆..Toll样受体及其对肠黏膜免疫的调节作用[J].动物营养学报,2016,(1):43-49,7.基金项目
国家自然科学基金（31472120）；黑龙江省自然科学基金（C201325）；黑龙江省农垦总局科技攻关项目（HNK125B-12-04）；黑龙江省大学生创新创业训练计划项目 （）
