动物营养学报Issue(1)：57-63,7.DOI:10.3969/j.issn.1006-267x.2016.01.009
能量感应网络 AMPK／SIRT1／PGC-lα对骨骼肌纤维类型转化调节
Energy Sensing Network AMPK/SIRT1/PGC-lαInvolved in Regulating Skeletal Muscle Fiber Type Transformation
摘要
Abstract
AMP-activated protein kinase ( AMPK ) , peroxisome proliferator-activated receptor γco-activator 1α( PGC-1α) and silent information regulator 1 ( SIRT1) act as an orchestrated network to regulate the signal of cellular energy output, that is called energy sensing, to modulate energy metabolism, mitochondria and muscle fiber transformation of the whole body.This review extracted the new advances and summarized the critical roles of the AMPK/PGC-1α/SIRT1 energy network in regulating muscle fiber transformation, so as to provide references for livestock production and human nutrition.关键词
肌纤维类型转化/AMPK/SIRT1/PGC-lα/线粒体功能/能量代谢Key words
skeletal muscle fiber-type transformation/AMPK/SIRT1/PGC-lα/mitochondrial function/ener-gy metabolism分类
农业科技引用本文复制引用
文超越,段叶辉,李颖慧,郭秋平,孔祥峰,李凤娜..能量感应网络 AMPK／SIRT1／PGC-lα对骨骼肌纤维类型转化调节[J].动物营养学报,2016,(1):57-63,7.基金项目
国家重点基础研究发展计划（2013CB127305，2012CB124704）；国家自然科学基金（31110103909，31330075）；中科院 STS 项目 （）
