高等学校化学学报Issue(2)：224-231,8.DOI:10.7503/cjcu20150662
透明质酸修饰的介孔二氧化硅包覆金纳米棒的制备及在肿瘤化疗-热疗联合治疗中的应用
Preparation of Hyaluronic Acid-modified Mesoporous Silica-coated Gold Nanorods and Their Application in Chemo-Photothermal Therapy of Cancer
金新天 1佟倜 2刘刚 1李君哲 3孙丽丽 3王俊荣 3李俊锋 3李沛 4陈文庆 3王强3
作者信息
- 1. 吉林大学第二医院，长春 130041
- 2. 吉林省肿瘤医院，长春 130021
- 3. 吉林省肿瘤医院，长春 130021
- 4. 吉林农业大学医院，长春 130118
- 折叠
摘要
Abstract
A tumor-targeting multifunctional drug delivery system was obtained through modifying mesoporous silica-coated gold nanorods with biocompatible hyaluronic acid. The experimental results demonstrated hyalu-ronic acid could be modified on the surface of mesoporous silica through the formation of amide bond. The re-sulted drug carrier could realize enzyme-responsive drug release in the presence of hyaluronidase. UV-Vis spectra showed that the system had a high absorption in the near infrared region, thus exhibiting photothermal effect upon the near infrared light irradiation. Besides, cell experiments demonstrated the multifunctional drug carrier could effectively target CD44 over-expressed breast cancer cells. It could be accumulated in the tumor region through CD44 receptor mediated endocytosis. Combining chemo- and photothermal therapy resulted in improved tumor apoptosis efficiency.关键词
介孔二氧化硅/金纳米棒/透明质酸/化疗-热疗联合治疗Key words
Mesoporous silica/Gold nanorods/Hyaluronic acid/Chemo-photothermal therapy分类
化学化工引用本文复制引用
金新天,佟倜,刘刚,李君哲,孙丽丽,王俊荣,李俊锋,李沛,陈文庆,王强..透明质酸修饰的介孔二氧化硅包覆金纳米棒的制备及在肿瘤化疗-热疗联合治疗中的应用[J].高等学校化学学报,2016,(2):224-231,8.
