口腔疾病防治Issue(3)：150-153,4.DOI:10.12016/j.issn.2096-1456.2016.03.005
转酮醇酶样蛋白1在舌鳞状细胞癌中的表达及意义
Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning
摘要
Abstract
Objective To investigate the expression of TKTL1 ( transketolase-like protein 1 ) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma. Methods Immunohis-tochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer specimens and matched normal tis-sues. Results The positive expression ratio of TKTL1 protein in tongue squamous carcinoma tissues ( 68. 89%) was sig-nificantly higher than that in normal tissues ( 15. 56%) , and the difference was statistically significant (χ2 =26. 235, P<0. 01) . The high level of TKTL1 was not statistically correlated with age, gender and tumor differentiated degree ( P>0. 05) , however it was associated with TNM staging and lymph node metastasis ( P<0. 05) notably. Mantel-Cox demon-strated the survival time of patients with high TKTL1 expression was significantly lower than those with low TKTL1 expres-sions. Conclusion It suggests a high TKTL1 expression may be tightly related to the occurrence, development, progres-sion and prognosis of human tongue squamous cell carcinoma.关键词
转酮醇酶样蛋白1/舌/鳞状细胞癌/临床病理学参数/预后Key words
Transketolase-like protein 1/Tongue/Squamous cell carcinoma/Clinicopathological characteris-tics/Prognosis分类
医药卫生引用本文复制引用
岳增文,刘进忠,朱宝玉,陈争光..转酮醇酶样蛋白1在舌鳞状细胞癌中的表达及意义[J].口腔疾病防治,2016,(3):150-153,4.基金项目
河南省教育厅科学技术研究重点项目指导计划(14B320018) （14B320018）
