口腔疾病防治Issue(3)：158-161,4.DOI:10.12016/j.issn.2096-1456.2016.03.007
口服普萘洛尔治疗婴幼儿头颈部血管瘤的临床效果观察
Clinical observation of treating infantile head and neck hemangioma with oral propranolol
吴晓平 1张大明 2陈伟良2
作者信息
- 1. 中山大学附属汕头医院·汕头市中心医院口腔科，广东 汕头 515031
- 2. 中山大学孙逸仙纪念医院口腔颌面外科
- 折叠
摘要
Abstract
Objective To evaluate the treatment effect and drug safety of treating infantile head and neck hemangioma with oral propranolol. Methods Oral propranolol was applied to 68 infants( male 20 cases, female 48 cases, from 1 to 9-month-old, with an average age of 4. 2 month) with heamngiomas. The daily dose of propranolol was increased from 0. 5 mg/kg at the first day to 1. 0 mg/kg at the second day, and to 2 mg/kg at the third day. The daily dose was given e-qually every 8 hours. A therapy dose of 2 mg/kg/day was given until 1-year old, and the patients were visited every month. The changes of tumor size, texture, color and adverse effects were monitored . The short-term results were evalua-ted and adverse effects after medication were observed and managed accordingly by Achauer criterion. Results Although side effects were noted in 23 cases ( 33. 8%) , most were mild adverse effects and propranolol therapy was continued after symptomatic treatment. 2 patients ( 2. 9%) were stopped therapy due to hypotension and abnormal liver function after drug administration. The results were evaluated using Achauer system, scale Ⅰ( poor) in 6 patients ( 8. 8%) , scale Ⅱ( moderate) in 11 patients( 16. 2%) , scale Ⅲ ( good) in 17 patients ( 25%) and scale Ⅳ ( excellent) in 32 patients ( 47. 1%) . Conclusion Oral propranolol treatment of infantile hemangioma has elicited high efficacy and tolerance with few expected adverse effects. It might be used as the first-line treatment for infantile head and neck hemangioma.关键词
普萘洛尔/血管瘤/脉管性疾病/头颈部/婴幼儿Key words
Propranolol/Hemangioma/Vascular anomalies/Head and neck/Infant分类
医药卫生引用本文复制引用
吴晓平,张大明,陈伟良..口服普萘洛尔治疗婴幼儿头颈部血管瘤的临床效果观察[J].口腔疾病防治,2016,(3):158-161,4.
