国际医药卫生导报2016，Vol.22Issue(3)：370-372,3.DOI:10.3760/cma.j.issn.1007-1245.2016.03.027
不同剂量非布司他对高尿酸血症伴痛风患者内皮素-1水平的影响
Impact of different dose of Febuxostat on endothelin-1 level in patients with hyperuricemia complicated by gout
吴敏 1黄淑玉 1晏益民 1刘锋 1朱钊 1李玲 1廖世波1
作者信息
- 1. 432000 武汉科技大学附属孝感医院内分泌科
- 折叠
摘要
Abstract
Objective To explore the impact of different doses of Febuxostat and allopurinol on endothelin-1 (ET-1) level in patients with hyperuricemia complicated by gout.Methods From January to June 2014,48 patients with hyperuricemia and gout (remission stage) treated in our hospital were randomly divided into three groups,and each group was given allopurinol 300 mg/d (G1),Febuxostat 40 mg/d (G2) or Febuxostat 80 mg/d (G3) for 24 weeks.The levels of uric acid and ET-1 were determined before treatment,after 12,24 weeks' treatment.Results The levels of ET-1 and uric acid both declined significantly in 3 groups after 12,24 weeks' treatment compared with before treatment (P＜0.05);but there were no statistically significant differences in the levels of ET-1 or uric acid among three groups after 12,24 weeks' treatment (P＞0.05).The correlation analysis showed that serum ET-1 was positively correlated with uric acid (r=0.461,P=0.000).Conclusions 40 mg,80 mg Febuxostat and allopurinol could reduce the levels of ET-1 and uric acid and improve vascular endothelial function in patients with hyperuricemia complicated by gout.Futher observation is still needed to clarify the mechanism of large-dose Febuxostat in reducing ET-1 level.关键词
非布司他/高尿酸血症/痛风/内皮素-1Key words
Febuxostat/Hyperuricemia/Gout/Endothelin-1引用本文复制引用
吴敏,黄淑玉,晏益民,刘锋,朱钊,李玲,廖世波..不同剂量非布司他对高尿酸血症伴痛风患者内皮素-1水平的影响[J].国际医药卫生导报,2016,22(3):370-372,3.
