摘要
Abstract
Objective To investigate the clinical curative effect of bismuth-containing quadruple therapy for peptic ulcer complicated with helicobacter pylori infection.Methods 208 patients with peptic ulcer complicated with helicobacter pylori infection admitted into our hospital from July,2013 to April,2015 were selected for prospective study and were randomly divided into an experimental group and a control group,104 cases for each group.The experimental group was treated with quadruple therapy of amoxicillin,pantoprazole,furazolidone,and colloidal bismuth pectin and the control group with triple therapy of amoxicillin,pantoprazole,and clarithromycin.The treatment effectiveness evaluation of gastric ulcer,andduodenal ulcer,helicobacter pylori eradicated rate,conditions of drug adverse reactions,etc.of these two groups were compared.Results The significance of thetreatment effectiveness evaluation of gastric ulcer and duodenal ulcerwas better in the experimental group (95.00％ and 98.44％) than in the control group(75％ and 83.33％),with statistical differences(P＜0.01).The helicobacter pylori eradicated rates of gastric ulcer and duodenal ulcer were better in the experimental group (90.00％ and 95.31％) than in the control group(68.18％ and 71.67％),with statistical differences(P＞0.01).There was no statistical difference in the incidence of drug adverse reactions bwtween these two groups(6.72％ vs.3.84％,P＞0.05).Conclusions Bismuth-containing quadruple therapy in the treatment of peptic ulcer with helicobacter pylori infection has significant clinical curative effect and better safety.It is of reference.关键词
含铋剂四联疗法/消化性溃疡/幽门螺杆菌/治疗效果/根除率/药物不良反应Key words
Bismuth-containing quadruple therapy/Peptic ulcer/Helicobacter pylori/Curative effect/Eradicated rate/Drug adverse reaction
