王平凡 1张东生 1李岚 1邱娜 1张晶晶 1卫陇 1拓晓娟1
作者信息
- 1. 兰州市第二人民医院病理科，兰州 730000
- 折叠
摘要
Abstract
Objective: To investigate the relationship between two kinds of gallbladder mucosa metaplasia and gallbladder adenocarcinoma by observing the expression of MUC5B, Villin, P53 in gallbladder mucosa pyloric gland metaplasia, intestinal metaplasia and gallbladder adenocarcinoma.Methods: A total of 120 cases were collected in pathology department of the second people’s hospital of Lanzhou from January 2013 to January 2015, including 40 cases of gallbladder mucosa pyloric gland metaplasia, 40 cases of intestinal metaplasia and 40 cases of gallbladder adenocarcinoma. Immunohistochemical method was used to detect the expression of MUC5B, Villin, P53 in gallbladder mucosa pyloric gland metaplasia, intestinal metaplasia and gallbladder adenocarcinoma.Results:Positive expression rate of MUC5B was 95.00% (38/40), 75.00% (30/40), 27.50% (11/40) in gallbladder mucosa pyloric gland metaplasia, intestinal metaplasia, gallbladder adenocarcinoma respectively; positive expression rate of Villin was 0.00% (0/40), 87.50% (35/40), 22.50% (9/40) in three groups respectively; positive expression rate of P53 was 2.50% (1/40), 7.50% (3/40), 80.00% (32/40) in three groups respectively. Comparison between three groups, positive expression rate of MUC5B in pyloric gland and intestinal metaplasia was obviously higher than that of gallbladder adenocarcinoma, the difference was statistically signiifcant (χ2=42.754,P=0.001); positive expression rate of Villin in the intestinal metaplasia was obviously higher than that of pyloric gland metaplasia and gallbladder adenocarcinoma, the difference was statistically signiifcant (χ2=71.124,P=0.001); P53 positive expression rate in the gallbladder adenocarcinoma was obviously higher than that of pyloric gland and intestinal metaplasia, the difference was statistically signiifcant (χ2=71.667,P=0.001). MUC5B, Villin positive expression rate decreased in turn among the three groups; P53 positive expression rate increased in turn among the three groups. Conclusion:hTe pyloric gland and intestinal metaplasia may participate in the occurrence of gallbladder carcinoma.关键词
胆囊黏膜/幽门腺化生/肠上皮化生/胆囊腺癌/MUC5B/Villin/P53Key words
gallbladder mucosa/pyloric gland metaplasia/intestinal metaplasia/gallbladder adenocarcinoma/MUC5B/Villin/P53
