中国实用神经疾病杂志Issue(1)：5-7,3.
椎动脉发育不全对小脑后下动脉供血区脑灌注的影响
Effect of vertebral artery hypoplasia on the territory-related perfusion of posterior inferior cerebellar artery
摘要
Abstract
Objective To investigate the effect of vertebral artery hypoplasia on the territory perfusion of posterior inferi-or cerebellar artery (PICA).Methods 244 patients with vertigo or dizziness (age≥30 years old)from December 2014 to July 201 5 were selected as subjects who underwent brain perfusion-weighted imaging (pWI)and three-dimensional dynamic con-trast-enhanced MRA (3D DCE-MRA).The perfusion figures of cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT)and time to peak(TTP)were obtained.The perfusion parameters including CBF,CBV,MTT and TTP val-ues were measured at PICA areas and at the opposite mirror-imaging areas.Relative perfusion parameter values (rCBF,rCBV, rMTT and rTTP)defined as the ratio of the shorter diameter side of vertebral artery to the mirror-imaging areas were calculat-ed.VAH was determined as diameter of less than 2mm or an asymmetry ratio of noless than 1.7:1 of bilateral vertebral arter-ies.The patients were divided into VAH group or non-VAH group according to the above-mentioned definition.Differences in clinical data and PWI parameters of cerebellum and medulla oblongata were compared between the two groups.Difference would be considered statistically significant if P <0.05.Results:A total of 1 14 patients were admitted,including 57 males and 57 females.There are 31 cases (27.2%)in VAH group including 5 cases on the left side of vertebral artery and 26 cases on the right and 83 cases in non-VAH group.There were significant differences in the number of rTTP (P=0.005)or rCBF (P=0. 031 )of less than 85% between two groups.Significant difference tended to emerge in rCBF.No significant difference existed in rMTT or rCBV of ≤85%.Conclusions VAH could cause the hypo-perfusion of relevant territories of posterior inferior cerebel-lar artery,mainly predominating TTP extension and CBF reduction.关键词
椎动脉发育不全/磁共振灌注成像/磁共振血管造影术Key words
Vertebral artery hypoplasia/perfusion-weighted Imaging/Magnetic Resonance Angiography分类
医药卫生引用本文复制引用
马乾坤,张道培,张杰文,张淑玲,鹿桂凤,尹所..椎动脉发育不全对小脑后下动脉供血区脑灌注的影响[J].中国实用神经疾病杂志,2016,(1):5-7,3.基金项目
国家自然科学基金面上项目(编号:81471203,代码:H0906) （编号:81471203,代码:H0906）
