中国实用神经疾病杂志Issue(3)：12-13,2.
异丙酚对高血压脑出血患者脑组织保护作用研究
Protective effect research of propofol for brain tissues in patients with hypertensive cerebral hemorrhage
胡汇敏 1李明强 1吴树宁 1周立文 1叶繁1
作者信息
- 1. 湖北文理学院附属医院 湖北襄阳市中心医院 襄阳 441021
- 折叠
摘要
Abstract
Objective To observe the influence of propofol for IL-1β and TNF-α in patients with hypertensive cerebral hemorrhage and its protective effect on the brain tissue. Methods Ninety patients with hypertensive cerebral hemorrhage re-ceived BHID and were divided into research group and control group according to the different preoperative anesthesia. The re-search group were treated with propofol (continuous infusion) combined with lidocainum (local infiltration anesthesia) while control group were treated with lidocainum (local infiltration anesthesia). Before surgery ,after 24 h and 48 h of surgery ,5 mL of venous blood was draw to detect the levels of IL-1βand TNF-α. For relief of brain swelling ,the dosage of DSMS ,mannitol and glycerin fructose of two groups were compared. Results The levels of IL-1β after 24 h and 48 h of surgery of research group were(4.6 ± 1.2)pg/mL and(5.4 ± 1.0)pg/mL and the levels of control group were(8.4 ± 1.6)pg/mL and(9.2 ± 1.6) pg/mL (P<0.05);the levels of TNF-αafter 24 h and 48 h of surgery of research group were(43.1 ± 12.3)pg/mL and(55.5 ± 12.8)pg/mL while the levels of control group were(74.8 ± 13.9)pg/mL and(81.8 ± 16.5)pg/mL ;the dosage of DSMS , mannitol and glycerin fructose of research group were(28.8 ± 3.9)mg ,(188.1 ± 12.4)g and(26.5 ± 6.7)g while the dosage of control group were(94.2 ± 9.1)mg ,(576.9 ± 26.3)g and(109.6 ± 12.3)g (P<0.05). Conclusion The intravenous infusion of propofol can effectively reduce the dosage of DSMS ,mannitol and glycerin fructose ,improve the higher intracranial pressure af-ter surgery and protect the brain tissue. Its mechanism may be correlated with the lower levels of IL-1βand TNF-α.关键词
异丙酚/利多卡因/高血压脑出血/脑组织保护Key words
Propofol/Lidocainum/Hypertensive cerebral hemorrhage/Brain protection分类
医药卫生引用本文复制引用
胡汇敏,李明强,吴树宁,周立文,叶繁..异丙酚对高血压脑出血患者脑组织保护作用研究[J].中国实用神经疾病杂志,2016,(3):12-13,2.
