摘要
Abstract
Objective To study the characteristics and its related factors of event related potential P300 in patients with epilepsy. Methods Fifty-three epilepsy patients and 21 age ,gender and educational levels matched healthy control subjects were involved into study. The event related potential P300 was evaluated and the related factors were explored by Pearson correla-tion analysis. Results Compared with the normal control group ,the latencies of P3 were longer ((361.32 ± 26.76) ms vs (311.27 ± 18.43) ms ,P<0.01) ,while the amplitudes were decreased ( (3.38 ± 1.52)μV vs (6.79 ± 1.93)μV ,P<0.01)in epilepsy group. There were positive correlations between P3 latency and duration of the disease ,frequency of seizures attack , the duration of seizures (P<0.05) ,negative correlation between P3 latency and the onset age of illness (P<0.01) ,and there were negative correlations between P3 amplitude and duration of the disease ,frequency of seizures attack ,the duration of sei-zures (P<0.05) ,positive correlation between P3 amplitude and the onset age of illness(P<0.01). There were no significant correlations between patient age ,educational levels and antiepileptic drugs usage. Conclusion The epilepsy patients have cogni-tive dysfunction reflected in the abnormalities of event related potential P300 and the changes of it are correlated with the onset age of illness ,duration of the disease ,frequency of seizures attack ,and the duration of seizures.关键词
癫痫/事件相关电位/认知功能Key words
Epilepsy/Event related potential/Cognitive function分类
医药卫生
