吉林中医药Issue(2)：194-197,198,5.DOI:10.13463/j.cnki.jlzyy.2016.02.027
正交试验法优选新型关节止痛膏基质处方
Optimization of new joint of Guanjie Zhitonggao Patch by orthogonal experiment
摘要
Abstract
Objective To design a kind of melt pressure sensitive adhesive(HMPSA)matrix patch joint pain ointment,to further improve product performance,improve product efficacy. Methods Using L9(34 )orthogonal ex-periment method to index the content of capsaicin,combined with patches of early adhesive power,holding Sticky,peel strength,water vapor permeability,through visual analysis and variance analysis,preferably new joint pain ointment matrix prescription. Results The best HMPSA matrix formulation is SIS1161 60 g,liquid paraffin 40 g,terpene resin 70 g,25 g of zinc oxide. Conclusion The new joint pain ointment performance,good performance and adhesion prop-erties of the drug,sticking comfortable.关键词
关节止痛膏/热熔压敏胶/辣椒素/正交试验Key words
Guanjie Zhitonggao/hot melt pressure sensitive adhesive(HMPSA)/capsaicin/orthogonal experiment分类
医药卫生引用本文复制引用
杜有财,徐圣博,武惠斌,李静,王博,熊维政..正交试验法优选新型关节止痛膏基质处方[J].吉林中医药,2016,(2):194-197,198,5.基金项目
国家重大新药创制专项资金资助（2011ZX09501-001-02）；北京市科技型中小企业技术创新资金项目（Z13010101142）。 （）
