临床输血与检验Issue(1)：39-42,4.DOI:10.3969/j.issn.1671-2587.2016.01.013
血清3种肿瘤标志物检测在卵巢肿瘤诊断与临床分期中的应用
Detection of Three Tumor Markers in Diagnosis and Clinical Staging of Ovarian Neoplasm
孙业富 1张志锋 1夏爱萍 2陈桂明2
作者信息
- 1. 225009 江苏省扬州市职业大学医学院
- 2. 苏州大学附属高邮市人民医院
- 折叠
摘要
Abstract
ObjectiveTo study and evaluate the application value of HE4, CA125 and PDGF-BB detections for diagnosis and clinical staging of ovarian malignant tumors .Methods216 patients were divided into two groups. Group one (premenopausal group) included26 cases of malignant ovary tumor and53 cases of benign ovary tumor, and60 cases of healthy women as control. Group two (emenopausal group) comprised of50 cases of malignant ovary tumor,87 cases of benign ovary tumor and108 cases of healthy women. HE4, CA125 and PDGF-BB in sera of patients were detected with ICMA and ELISA and the clinical application value in diagnosis of malignant ovarian tumor was analyzed.Results The levels of HE4, CA125 and PDGF-BB in the cases of malignant ovary tumor were significantly higher than those of benign tumors and healthy women (P <0.01). Spearman correlation analysis was staticstically significantly and HE4 was the highest correlation (r=0.613). The sensitivity of HE4 and CA125 was higher than that of PDGF-BB (P <0.05) while no difference was observed between HE4 and CA125 (P>0.05). At the same time, the specificity and accuracy of HE4 reached88.1% and87.1%, respectively when the level of36.5pmol/L was taken as the threshold value in premenopausal group. In the menopausal group, however, the specificity and accuracy were found to be93.5% and88.7% respectively if the cut-off value of56.8pmol/L was used.Conclusion Mornitoring of the three seral tumor markers of serum HE4, CA125 and PDGF-BB possesses a practical significance in helping to master the situation of patients, efficacy of treatments, and assessment of prognosis of malignant ovarian tumors.关键词
卵巢肿瘤/肿瘤标志物/人附睾上皮分泌蛋白4/血小板源性生长因子Key words
Ovarian neoplasm/Tumor marker/Human epididymis protein4/Vascular endothelial growth factor分类
医药卫生引用本文复制引用
孙业富,张志锋,夏爱萍,陈桂明..血清3种肿瘤标志物检测在卵巢肿瘤诊断与临床分期中的应用[J].临床输血与检验,2016,(1):39-42,4.
