摘要
Abstract
ObjectiveTo investigate the correlation between HBsAg quantitation, HBeAg and HBV DNA load detection and HBV genotyping in the positive HBeAg patients with chronic hepatitis B.Methods The data of154 cases of HBeAg positive patients with chronic hepatitis B were collected, who were primarily diagnosed in an infectious disease hospital from January to December,2014.Results Forty-eight patients were infected with HBV genotype B ,104 with HBV genotype C and2 with neither genytype B nor genotype C. The HBsAg level was higher [4.0 (2.6,5.5) log10IU/ml] and HBV DNA load [6.8(4.3,8.5) log10 copies/ml] in patients infected with HBV genotype C was higher than other genotypes [4.0(2.6,5.0) log10IU/ml,6.5 (3.7,7.8) log10 copies/ml] (P <0.05). However, there was no statisticalsignificance of HBeAg level between genotype C and other genotypes. The Sperman correlation analysis showed that HBsAg had a negative correlation with HBeAg (r = -0.42,P =0.005) or HBV DNA(r =-0.43,P =0.03).Conclusions Correlation of HBsAg quantitation exists with HBeAg load, HBV DNA Level, and HBV genotypes. These markers should be jointly detected in the diagnosisof positive HBeAg patients with chronic hepatitis B.关键词
乙型肝炎表面抗原/乙型肝炎E抗原/脱氧核糖核酸/基因分型Key words
HBsAg/HBeAg/DNA/Genotype分类
医药卫生
