农药学学报Issue(1)：119-123,5.DOI:10.16801/j.issn.1008-7303.2016.0015
丹皮酚衍生物--3-羟基-1-（2-羟基-4-甲氧基苯）-3-（2′-溴苯）-1-丙酮的合成及其抗菌活性
Synthesis and antimicrobial activity of a paeonol derivative：3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3- (2'-bromophenyl)-1-acetone
摘要
Abstract
Paeonol was isolated from the root of Paeonia Suffruicosa. A derivative of paeonol, 3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-(2'-bromophenyl)-1-acetone, was synthesized by nucleophilic addition of paeonol with 2-bromobenzaldehyde at room temperature in a yield of 78.6%. The structure of this compound was identified by UV, IR, MS, NMR and elemental analyses and was confirmed by X-ray analysis. It belongs to monoclinic crystallographic system with space groupP2(1)/n anda = 0.993 80(15) nm,b = 0.806 17(12) nm,c = 1.925 1(3) nm,α = 90.0(2)°,β = 103.287(2)°,γ =90(2)°,V = 1.501 0(4) nm3,Dc = 1.554 mg/m3,μ = 2.751 mm–1,F(000) = 712,Z = 4,R1 = 0.029 0,ωR2 = 0.066 0,R(int) = 0.032 2. The minimum inhibitory concentration (MIC) of this compound against plant pathogenic fungi of Sclerotinia sclerotiorum and Botrytis cinerea were 0.36 and 0.48 g/L, and MIC value against Shigella flexneri 51065 and Staphylococcus aureus ATCC25925 were 0.02 and 0.06 g/L, respectively.关键词
丹皮酚/2-溴苯甲醛/合成/结构表征/抗菌活性Key words
paeonol/2-bromobenzaldehyde/characterization/synthesis/antimicrobial activity分类
化学化工引用本文复制引用
刘存芳..丹皮酚衍生物--3-羟基-1-（2-羟基-4-甲氧基苯）-3-（2′-溴苯）-1-丙酮的合成及其抗菌活性[J].农药学学报,2016,(1):119-123,5.基金项目
陕西省科技厅社会发展科技攻关项目(2015SF270)；陕西省教育厅服务地方专项项目(15JF013) （2015SF270）
