天津中医药Issue(1)：26-30,5.DOI:10.11656/j.issn.1672-1519.2016.01.07
燮理糖肾颗粒对2型糖尿病肾病大鼠高黏高脂微循环障碍的实验研究
Experimental study of Xieli Tangshen granules on the high viscosity and high fat microcirculation disturbance in rats with 2 type diabetic nephropathy
摘要
Abstract
Objective] Taking Bushen Xiezhuo as the theoretical basis, using Bushen Xiezhuo Huayu method preparation Xieli Tangshen granule, and to observe the effects of it on high fat, high viscosity and microcirculation in insulin resistance with diabetic nephropathy rats. [Methods] The left kidney of rat was excised, and the rats were fed with high glucose and high fat diet for six weeks. Then, randomly divided into six groups:sham operation group, model group, three different dose groups, and positive control group. Next, detect rats blood glucose, glycosylated hemoglobin(HbA1c), blood and urine, urinary protein, creatinine clearance rate of indicators and observe effect of Xieli Tangshen granules on the carotid artery thrombus formationof rats. [Results] Compared with sham operation group, blood glucose, HbA1c, serum lipid, blood viscosity and urine protein increased in the model group, and insulin sensitivity index (ISI)and creatinine clearance rate decreased, which indicated that insulin resistance diabetic nephropathy model was established, and was accompanied by high cholesterol. Compared with the model group, Xieli Tangshen granules 8, 16 g crude drug dosage group, the levels of blood glucose, HbA1c, TG, whole blood viscosity decreased obviously, urinary protein decreased, creatinine clearance rate increased and extension the carotid artery thrombus formation time. [Conclusion] Xieli Tangshen granules can lower blood glucose and improve ISI and protect renal function and can decrease viscosity, blood fat and extend the carotid artery thrombus formation time on rats with insulin resistance dia-betic nephropathy, and the results suggest that the drug has cardiovascular protective effect.关键词
燮理糖肾颗粒/糖尿病肾病/胰岛素抵抗/高黏/高脂血症/微循环障碍Key words
Xieli Tangshen granule/diabetic nephropathy/insulin resistance/high viscosity/hyperlipemia/microcirculation disturbance分类
医药卫生引用本文复制引用
柴霞,苏文弟,秦莉,赵蓬,张柏林..燮理糖肾颗粒对2型糖尿病肾病大鼠高黏高脂微循环障碍的实验研究[J].天津中医药,2016,(1):26-30,5.基金项目
全国名老中医传承工作室自选课题。 （）
