天津中医药Issue(1)：39-42,4.DOI:10.11656/j.issn.1672-1519.2016.01.10
多指标正交设计优选芪防鼻敏颗粒水提醇沉工艺
Optimization of aqueous extraction-alcohol precipitation technology for Qifang Bimin granules with multi-index orthogonally designed experiments
摘要
Abstract
Objective] To investigate the technology of optimal water extraction and alcohol precipitation for Qifang Bimin granules with Multi-index. [Methods] The study employed the extraction rate of astragaloside IV and paeoniflorin as evaluation indexes to investigate extraction conditions. We also investigate alcohol precipitation condition in the metastatic rate of astragaloside IV and paeoniflorin as detective index. [Results] The optimal water extraction and alcohol precipitation was extracted 3 times, with 12 folds the amount of water, 1.5 h for each time. The extracts were concentrated to the relative density of 1.15~1.20 (60 ℃) with the concentration of alcohol precipitation 60%. [Conclusion] Optimized water extraction and alcohol precipitation technology was reasonable and feasible and it could provide a reference for industrial production of Qifang Bimin granules.关键词
黄芪甲苷/芍药苷/水提醇沉/多指标Key words
astragaloside IV/paeoniflorin/water extraction and alcohol precipitation/multi-index分类
医药卫生引用本文复制引用
薛丹,倪健,张鹏,杨春静,赵阳,夏振文,尹兴斌,李友林..多指标正交设计优选芪防鼻敏颗粒水提醇沉工艺[J].天津中医药,2016,(1):39-42,4.基金项目
国家自然科学基金面上项目（81173563）；北京市科学技术委员会“十病十药”研发项目（Z141100002214018）。 （）
