天津中医药Issue(1)：43-46,4.DOI:10.11656/j.issn.1672-1519.2016.01.11
火焰原子吸收分光光度法测定丹红注射液中钠、钾离子的含量
Determination of sodium and potassium in Danhong injection by atomic absorption spectrometry
摘要
Abstract
Objective] To establish and validate the determination method of the content of sodium ion and potassium ion in Danhong injection by atomic absorption spectrometry (AAS). [Methods] Microwave digestion system was applied to deteriorate samples, and the content of sodium ion and potassium ion was determined by AAS. [Results] The calibration curve of sodium was liner (r=0.999 8) in the range from 0.1 to 0.6 mg/L. The average recovery was 101.1%with RSD 1.8%. The limit of detection was 5.3μg/L. The calibration curve of potassium was liner (r=0.999 8) in the range from 0.1 to 0.8 mg/L. The average recovery was 99.8% with RSD 2.3%. The limit of detection was 7.7 μg/L. The determination results of 10 batches Danhong injection sample showed that the content of sodium ion was 562.3 to 734.7 mg/L and potassium ion was 206.9 to 314.4 mg/L. [Conclusion] The method is simple and accurate and can be used for determination of the contents of sodium ion and potassium ion in Danhong injection. The accurate quantitative determination method can be promoted to quality control of Danhong injection.关键词
丹红注射液/钠离子/钾离子/火焰原子吸收分光光度法Key words
Danhong injection/sodium ion/potassium ion/atomic absorption spectrometry分类
医药卫生引用本文复制引用
王琰,焦玉娇,朱彦,王跃飞,杨静..火焰原子吸收分光光度法测定丹红注射液中钠、钾离子的含量[J].天津中医药,2016,(1):43-46,4.基金项目
十二五重大新药创制科技重大专项（2013ZX 09201020），国家自然科学基金（81503239）。 （）
