中国组织工程研究Issue(52)：8480-8486,7.DOI:10.3969/j.issn.2095-4344.2015.52.021
生物降解材料复合成骨因子在骨科应用研究中的进展
Biodegradable materials combined with osteogenic factor in orthopaedics
刘大海 1李开南 1魏友华1
作者信息
- 1. 遵义医学院-成都大学附属医院，四川省成都市610081
- 折叠
摘要
Abstract
BACKGROUND:Biodegradable implants cannot only rebuild bone defect site, moreover, with the gradual degradation of the materials, new bone tissue can completely replace the graft materials to fil bone defects. OBJECTIVE:To summarize the research progress of biodegradable materials combined with osteogenic factor in orthopedics. METHODS: We took the “biodegradable materials, factors, cel active factor, bone tissue engineering” as the search terms in Chinese and English, respectively, to retrieve the related literatures from PubMed, Wanfang and CNKI database during 2000 to 2015 by computer. RESULTS AND CONCLUSION: Biodegradable medical polymer materials can be divided into natural polymer materials and synthetic biodegradable materials. Natural polymeric materials have good biocompatibility, but poor mechanical strength. The mechanical strength of synthetic biodegradable materials is higher than that of natural polymer materials, but the synthetic biodegradable materials are likely to cause local accumulation of acidic substances, produce local inflammation. The biodegradable medical polymer materials combined with osteogenic factor can improve the mechanical strength and osteoinductive ability of materials, but as a bone repair material, it stil has many problems to be solved.关键词
生物材料/骨生物材料/生物降解材料/成骨因子/降解/修复分类
医药卫生引用本文复制引用
刘大海,李开南,魏友华..生物降解材料复合成骨因子在骨科应用研究中的进展[J].中国组织工程研究,2015,(52):8480-8486,7.
