中国组织工程研究Issue(52)：8517-8521,5.DOI:10.3969/j.issn.2095-4344.2015.52.027
雷帕霉素与紫杉醇洗脱支架置入治疗冠状动脉病变的有效性
Efficacy of rapamycin and paclitaxel eluting stent implantation in treatment of coronary artery disease
摘要
Abstract
BACKGROUND: The clinical effect of drug-eluting stent implantation in treatment of coronary artery disease is good, but there may be some differences in the therapeutic effect between different stents. OBJECTIVE:To compare the clinical effect of different stent implantation in treatment of coronary artery disease. METHODS:A total of 278 patients with coronary artery disease were enroled and al underwent coronary artery stent implantation treatment, of which 91 patients underwent implanted rapamycin eluting stent, 92 patients underwent implanted paclitaxel eluting stent, and 95 patients underwent implanted bare metal stents. Al the patients were folowed up for 12 months after stents implantation. The occurrence of adverse cardiac events such as death, myocardial infarction, and the occurrence of coronary restenosis and host reaction were recorded. RESULTS AND CONCLUSION:The rates of coronary artery stenosis, acute myocardial infarction, coronary artery bypass grafting or second-time percutaneous coronary interventional therapy in the paclitaxel eluting stent and rapamycin eluting stent groups were al lower than those in the bare metal stent group (P< 0.05). There were no significant differences in the above indicators between paclitaxel eluting stent and rapamycin eluting stent groups (P> 0.05). There was no significant difference in the mortality between these three groups (P> 0.05). There was no stent shift, shedding, breakage, bad implantation position, leukocytosis, thrombocytopenia and hemolysis in these three groups. These results demonstrate that the therapeutic effects of these two kinds of drug-eluting stents are al good enough, and better than those of bare metal stents.关键词
生物材料/材料相容性/冠状动脉支架/药物洗脱性支架/雷帕霉素洗脱支架/紫杉醇洗脱支架/裸金属支架/冠状动脉病变分类
医药卫生引用本文复制引用
杨俊,陈冬林,陈银朝,陈新敬..雷帕霉素与紫杉醇洗脱支架置入治疗冠状动脉病变的有效性[J].中国组织工程研究,2015,(52):8517-8521,5.基金项目
福建省卫生厅青年科研项目(2012-2-10)；福建省卫生厅面向农村推广项目(2012024)Funding:the Young Scientific Research Project of Fujian Provincial Health Department, No.2012-2-10 （2012-2-10）
the Rural Extension Project of Fujian Provincial Health Department, No.2012024 （）
