现代医药卫生Issue(3)：325-327,3.DOI:10.3969/j.issn.1009-5519.2016.03.002
普瑞巴林联合依帕司他和甲钴胺治疗痛性糖尿病周围神经病变的临床疗效
Efficacy of pregabalin combined with epalrestat and methylcobalamin in treating painful diabetic peripheral neuropathy
摘要
Abstract
Objective To evaluate the efficacy and safety of pregabalin combined with epalrestat and methylcobalamin in the treatment of painful diabetic peripheral neuropathy (PDPN). Methods Eighty patients with PDPN were randomly divided into the pregabalin group(A,n=40)and pregabalin combined with epalrestat and methylcobalamin(B,n=40).The two groups were given the therapy of controlling blood sugar level and improving circulation for 4 weeks. The pain intensity change before treat-ment and in 4 weeks after treatment was assessed with the Visual Analogue Scale (VAS). The quality of life was evaluated by the short form of World Health Organization Quality of Life(WHOQOL-100),too. Moreover,the nerve conduction velocity(NCV) was detected and the adverse drug reactions were recorded. Results The VAS scores after 4-week treatment in the two groups were significantly decreased compared with before treatment and the quality of life was significantly improved , the differences were sta-tistically significant (P<0.05),moreover the pain alleviation and living quality improvement in the group B were superior to the group A(P<0.05). After treatment,NCV in the group A had no obvious improvement compared with before treatment(P>0.05). However,NCV in the group B was obviously increased compared with before treatment,moreover NCV in the group B was signifi-cantly increased compared with the group A(P<0.05). The occurrence rate of adverse reactions had no statistical difference between the two groups(P>0.05). Conclusion Pregabalin combined with epalrestat and methylcobalamin has better effect than single pre-gabalin for treating PDPN,moreover without increasing the risk of increasing adverse drug reactions.关键词
糖尿病周围神经病变/周围神经系统疾病/神经痛/普瑞巴林/依帕司他/甲钴胺/药物疗法,联合Key words
Diabetic peripheral neuropathy/Peripheral nervous system diseases/Neuralgia/Pregabalin/Epal-restat/Methycobal/Drug therapy,combination引用本文复制引用
沈唯薇,胡文静,邓敏,范小云,龙敏,谢宗义..普瑞巴林联合依帕司他和甲钴胺治疗痛性糖尿病周围神经病变的临床疗效[J].现代医药卫生,2016,(3):325-327,3.基金项目
重庆市科委自然科学基金面上项目（CSTC2013jcyjA10054）；重庆市卫生局医学科研计划项目（2013-1-018）。 （）
