现代医药卫生Issue(3)：338-339,342,3.DOI:10.3969/j.issn.1009-5519.2016.03.006
胸腔积液细胞块联合免疫组化在肺腺癌与间皮细胞增生鉴别诊断中的应用
Application of pleural effusion cell block combined with immunohistochemistry in differentiation diagnosis of lung ade-nocarcinoma and mesothelial cell hyperplasia
摘要
Abstract
Objective To investigate the role of cell block combined with immunohistochemical method in the differen-tial diagnosis of lung adenocarcinoma pleural effusion and mesothelial cell hyperplasia. Methods The benign and malignant di-agnosis in 80 cases of pleural effusion was carried out by using the smear ,cell block and immunohistochemical method. Results E-cadherin,TTF-1 and CK7 had 100%positive or focal positive in lung adenocarcinoma,vim and CR were negative. In the smear detection,there were 33 cases of adenocarcinoma among 80 samples,24 cases were negative,23 cases were undetermined diagno-sis. In the smear+cell block+immunohistochemistry detection ,there were 48 cases of adenocarcinoma among 80 samples ,31 cases were negative and 1 case was undetermined diagnosis. The sensitivity for diagnosing adenocarcinoma pleural effusion had statisti-cal difference between the smear and the smear+cell block+s immunohistochemistry (χ2=5.63,P<0.05). The sensitivity for diagnos-ing the negative pleural effusion had no statistical difference(χ2=0.24,P>0.05). Among 80 samples,23 cases could not be clearly diagnosed by the smear method,while 1case was not diagnosed by the mear+cellblock+immunhistochemistry method,the differ-ence was statistically significant(χ2=21.62,P<0.01). Conclusion Adopting the smear+cell block+immunohistochemistry method can increase the sensitivity for diagnosing lung adenocarcinoma in pleural effusion.关键词
胸腔积液/染色与标记/免疫组织化学/腺癌/增生/上皮细胞Key words
Pleural effusion/Staining and labeling/Immunohistochemistry/Adenocarcinoma/Hyperplasia/Epithelial cells引用本文复制引用
林静,李美琼,农林琳..胸腔积液细胞块联合免疫组化在肺腺癌与间皮细胞增生鉴别诊断中的应用[J].现代医药卫生,2016,(3):338-339,342,3.基金项目
广西壮族自治区卫生厅自筹经费科研课题（Z2011183）。 （）
