摘要
Abstract
Objective To investigate the interventional treatment effect of statins in mouse nephrotoxic serum nephritis. Methods The mouse nephrotoxic serum nephritis model was established by nephrotoxic serum (NTS) injection. Then mice in the treatment group were intraperitoneally injected by 1,10,25 mg/kg atorvastatin at 24 h after the model construction. After NTS plus atorvastatin treatment for 7 d,all mice were killed,theblood and 24 h urine were collected for detecting serum urea nitrogen (BUN) and urinary protein level. Furthermore the renal histopathologic changes were detected. Results Compared with the model group,the body weight increase in the atorvastatin treatment group was not obvious,the urinary protein level was decreased (P<0.01),serum BUN level was reduced (P<0.01),and the degree of nephritis pathologica change was alleviated. The protective effect of atorvastatin showed the dose dependent manner ,the protective effect tin the 10 mg/kg treatment group was strongest. Conclusion Atorvastatin can effectively alleviate urinary protein in the experimental animal ,improves the glomerular filtration function,and has the protective effect for mouse immune nephritis.关键词
肾小球肾炎/血液/血尿素氮/免疫活性/炎症/吡咯类Key words
Glomerulonephritis/blood/Blood urea nitrogen/Immunocompetence/Inflammation/Pyrroles
