中国当代儿科杂志Issue(2)：123-129,7.DOI:10.7499/j.issn.1008-8830.2016.02.006
A型肉毒毒素注射治疗9~36月龄脑瘫患儿腓肠肌痉挛的前瞻性研究
Effect of botulinum toxin A injection in thetreatment of gastrocnemius spasticity in children aged 9-36 months with cerebral palsy：a prospective study
摘要
Abstract
ObjectiveTo investigate the long-term clinical efficacy and adverse effects of botulinum toxin-A (BTX-A) injection in the treatment of gastrocnemius spasticity in children aged 9-36 months with cerebral palsy. MethodsEighty children aged 9-36 months with cerebral palsy and gastrocnemius spasticity were selected and randomly divided into a BTX-A injection group and a conventional treatment group (n=40 each). The children in the BTX-A injection group received injections of BTX-A guided by color Doppler ultrasound and 4 courses of rehabilitation training after injection. Those in the conventional treatment group received 4 courses of the same rehabilitation training alone. Before treatment and at 1, 2, 3, and 6 months after treatment, the modiifed Tardieu scale (MTS) was applied to assess the degree of gastrocnemius spasticity, the values in the passive state measured by surface electromyography (sEMG) were applied to evaluate muscle tension, and the Gross Motor Function Measure (GMFM) was used to evaluate gross motor function.ResultsCompared with the conventional treatment group, the BTX-A injection group had signiifcantly greater reductions in MTS score and the values in the passive state measured by sEMG (P<0.05), as well as signiifcantly greater increases in joint angles R1 and R2 in MTS and gross motor score in GMFM (P<0.05). No serious adverse reactions related to BTX-A injection were found.ConclusionsBTX-A injection is effective and safe in the treatment of gastrocnemius spasticity in children aged 9-36 months with cerebral palsy.关键词
A型肉毒毒素/腓肠肌痉挛/超声/脑性瘫痪/儿童Key words
Botulinum toxin A/Gastrocnemius spasticity/Ultrasound/Cerebral palsy/Child引用本文复制引用
朱登纳,赵云霞,王明梅,王军,张玮,栗河舟,杨坡,熊华春,牛国辉,李三松..A型肉毒毒素注射治疗9~36月龄脑瘫患儿腓肠肌痉挛的前瞻性研究[J].中国当代儿科杂志,2016,(2):123-129,7.基金项目
郑州市科学技术局普通科技攻关项目（2015）（153PKJGG164）。 （）
