中国临床药理学杂志Issue(2)：99-101,3.DOI:10.13699/j.cnki.1001-6821.2016.02.001
尿肾损伤分子1和尿胱抑素 C在重症监护室万古霉素肾损伤早期诊断中的作用
Significance of urinary kidney injury molecule 1 and urinarycystatin C in early diagnosis of vancomycin-induced kidney injury in intensive care unit
钟丹锋 1宋于康 1董平1
作者信息
- 1. 浙江省温岭市第一人民医院 重症监护室，浙江温岭 317500
- 折叠
摘要
Abstract
Objective To explore the significance of urinary kidney in-jury molecule 1 ( KIM -1 ) and urinarycystatin C in early diagnosis of vancomycin-induced kidney injury.Methods A total of 180 patients given vancomycin were divided into kidney injury group ( n=32) and non-kidney injury group ( n=148 ) according to the occurrence of vanco-mycin-induced kidney injury.The difference of serum creatinine , uri-nary cystatin C , urinary KIM -1 were observed before treatment , after 6 , 12 , 24 , 48 h treatment.And the reciver operating characteristic ( ROC) curve was used to explore the significance of urinary KIM -1 and urinary cystatin C in early diagnosis of vancomycin -induced kidney inju-ry.Results The urinary creatinine after 48 h treatment in the kidney in-jury group was significantly higher than that in the non -kidney injury group (P<0.05).The urinary cystatin C after 12, 24, 48 h treatment in the kidney injury group was significantly higher than that in the non -kidney injury group ( P<0.05 ) .The urinary KIM -1 after 6 , 12 , 24 , 48 h treatment in the kidney injury group was significantly higher than that in the non -kidney injury group ( P<0.05 ).The areas under the curve of urinary cystatin C and urinary KIM -1 were respectively 0.783 and 0.884 , the sensitivity were respectively 0.864 and 0.936 , thespecificity were respectively 0.784 and 0.856.Conclusions Urinary cystatin C and urinary KIM-1 were helpful bio-markers for early diagnosis of vancomycin -induced kidney injury in patients , and the accuracy of urine KIM -1 was better.关键词
肾损伤分子1/胱抑素C/万古霉素/肾损伤Key words
kidney injury molecule 1/cystatin C/vancomycin/kidney injury分类
医药卫生引用本文复制引用
钟丹锋,宋于康,董平..尿肾损伤分子1和尿胱抑素 C在重症监护室万古霉素肾损伤早期诊断中的作用[J].中国临床药理学杂志,2016,(2):99-101,3.
