中国临床药理学杂志Issue(2)：105-107,3.DOI:10.13699/j.cnki.1001-6821.2016.02.003
丹参多酚酸盐治疗冠心病的临床疗效及安全性
Clinical effect and safety of salvia miltiorrhiza polyphenols in treatment of coronary atherosclerotic heart disease
摘要
Abstract
Objective To evaluate the clinical effect and safety of salvia miltiorrhiza polyphenols in the treatment of coronary atherosclerotic heart disease.Methods Sixty -six patients with coronary atherosclerotic heart disease were randomly divided into experiment group ( n=32 ) and control group ( n=34 ).Patients in experiment group were treated with salvia miltiorrhiza polyphenols 200 mg+0.9%NaCl 250 mL, intravenous drip, qd for 2 weeks;patients in control group treated with salvia injec-tion 30 mL+0.9%NaCl 250 mL, intravenous drip, qd for 2 weeks.The total amount of exercise metabolic , exercise-induced angina onset time , exercise-induced low pressure of 1 mm ST-off time, angina attacks, clinical efficiency and adverse drug reaction of the two groups were observed.Results Total efficacy was 87.50% in experiment group , significantly higher than 61.76% in control group ( P <0.05 ).The clinical index of the two groups were significantly improved after treatment ( P <0.05 ).The dosage of nitroglycerin and incidence of angina pectoris in experiment were significant lower than those of control group ( P<0.05 ).The incidence rate of adverse reactions had no statisti-cal difference ( 6.25% vs 8.82%, P >0.05 ).Conclusion Salviamiltiorrhiza polyphenols in the treatment of coronary atherosclerotic heart disease was effective and safe , which can re-duce the angina attacks.关键词
冠心病/丹参多酚酸盐/心绞痛Key words
coronary atherosclerotic heart disease/salvia miltiorrhiza polyphenols/angina分类
医药卫生引用本文复制引用
何训,吕世文,郭佳奕..丹参多酚酸盐治疗冠心病的临床疗效及安全性[J].中国临床药理学杂志,2016,(2):105-107,3.基金项目
金华市科技局社会发展类一般基金资助项目 （）
