中国临床药理学杂志Issue(2)：108-110,3.DOI:10.13699/j.cnki.1001-6821.2016.02.004
利伐沙班和依诺肝素预防人工膝关节置换术后下肢深静脉血栓的临床研究
Clinical effect of rivaroxaban and enoxaparin on the prevention of lower deep vein thrombosis after artificial knee joint replacement
摘要
Abstract
Objective To investigate the clinical effect of rivaroxaban and enoxaparin on the prevention of lower deep vein thrombosis after arti-ficial knee joint replacement.Methods A total of 120 patients who ex-perienced first artificial knee replacement surgery were divided into two groups.And 12 h after surgery , 60 patients in treatment group were gi-ven oral rivaroxaban 10 mg · d -1 , 60 patients in control group received subcutaneous enoxaparin heparin 4000 IU · d-1.The treatment of two groups all lasted for 14 d.The incidence of deep vein thrombosis , bleed-ing, complications and long -term efficacy of patients between groups were compared.Results There were no statistical difference between treatment group and control group in terms of activated partial thrombo-plastin time ( APTT ) , blood platelets count ( PLT ) and D -dimer ( all P>0.05 ) .The incidence rate of lower deep vein thrombosis in treatment group was 11.67%( 7/60 ) and control group 15.00%( 9/60 ) , they had no significant difference ( P>0.05 ).There were no statistical difference between two groups in postoperative drainage , total amount of blood transfusion and hemorrhagic index ( all P>0.05 ).The incidence rate of petechiae in treatment group was 23.33%(14/60), and 18.33(11/60) in control group (P>0.05).There were no sta-tistical difference between two groups in visual analogue scale ( VAS) pain scores and swollen knee at first three days and seven days after operation (all P>0.05).There were no statistical difference between two groups in knee mobility and keen society score ( KSS) function scores during the follow-up half a year after operation (all P>0.05).The knee mobility and KSS function scores during the follow-up one year after operation in treatment group were higher than that in control group ( all P <0.05 ).Conclusion Rivaroxaban and enoxaparin had equivalent efficacy on the prevention of venous thrombosis after artificial knee joint replacement surgery.However, the long-term clinical effect of rivaroxaban was better .关键词
利伐沙班/依诺肝素/人工膝关节置换术/下肢深静脉血栓Key words
rivaroxaban/enoxaparin/artificial knee joint replacement/lower deep vein thrombosis分类
医药卫生引用本文复制引用
陈俊南,PRANESH Kumar Yadav,唐赢,易刚,郑元义,陈世荣..利伐沙班和依诺肝素预防人工膝关节置换术后下肢深静脉血栓的临床研究[J].中国临床药理学杂志,2016,(2):108-110,3.基金项目
2012年国家自然科学基金资助项目 （）
