中国临床药理学杂志Issue(2)：111-113,3.DOI:10.13699/j.cnki.1001-6821.2016.02.005
健脾调中散对功能性消化不良患儿的临床疗效及胃肠动力作用研究
Clinical effect of Jianpi tiaozhong powder in the treatment of children with functional dyspepsia and its influence on gastrointestinal motility
摘要
Abstract
Objective To evaluate the clinical effect of Jianpi tiaozhong powder in the treatment of children with functional dyspepsia ( FD) and its effects on the gastric motility.Methods Ninety children with FD were randomly divided into treatment group and control group , 45 cases in each group.Children in treatment group were given Jianpi tiaozhong powder one hour after the breakfast and supper , 10 mL for five to nine years old children and 20 mL for ten to fourteen years old children.Meanwhile , children in control group were given domperidone syrup orally, the doses of 5-7, 8-10 and 11-14 years old children were 5, 7 and 10 mL, separately.After one -month treatment, the clinical symptoms, side effect, electrogastrogram(EGG), motilin(MOT), soma-tostatin(SS) and gastrin(GAS) were recorded and compared before and after treatment.Results After treatment , the total efficiency of treatment group was 86.67%, significantly higher than that in control group, which was 75.56%( P<0.05 ).Improvement of symptoms in treatment group was more significant than that in control group( P<0.05 ).The percents of normal rhythm before meal were significantly higher than before treatment ( P<0.05 ).The motilin and somatostatin in treatment group were ( 235.7 ±19.4 ) , ( 18.8 ±2.5 ) pg · mL-1 , significantly lower than those in control group , which were ( 267.3 ±17.2 ) , ( 20.3 ±1.4 ) pg · mL-1.Gastrin in treatment group and control group were (168.6 ±17.2), (142.8 ±11.4) pg· mL-1, respectively (P<0.05).The motilin, somatostatin and gastrin after treatment were comparable than those before treatment in two groups ( P <0.05 ).There was no adverse drug reaction in two groups.Conclusion Jianpi tiaozhong powder had precise efficacy and slight side effect on children with FD.关键词
功能性消化不良/儿童/健脾调中散/胃肠动力Key words
functional dyspepsia/children/Jianpi tiaozhong powder/gastrointestinal motility分类
医药卫生引用本文复制引用
胡灵敏,周亚敏,梁小平,谢继承,邱夏桑..健脾调中散对功能性消化不良患儿的临床疗效及胃肠动力作用研究[J].中国临床药理学杂志,2016,(2):111-113,3.基金项目
台州市科技局基金资助项目 （）
