中国临床药理学杂志Issue(2)：129-131,3.DOI:10.13699/j.cnki.1001-6821.2016.02.011
卡培他滨单药或联合奥沙利铂同步放化疗对晚期直肠癌的临床疗效研究
Clinical research of capecitabine monotherapy or in combination with oxaliplatin concurrent chemoradiotherapy on patients with advanced colorectal cancer
摘要
Abstract
Objective To analyze the clinical efficacy of capecitabine monotherapy or in combination with oxaliplatin concurrent chemoradio-therapy on patients with advanced colorectal cancer.Methods Fifty-two patients with advanced colorectal cancer were randomly divided into treatment group and control group , 26 cases in each group.Two groups were all taken 6 mV X -ray irradiation, 5 times a week, totally five weeks.On the same time , control group was given capecitabine , twice a day, with the total dose of 1500-1700 mg· m-2 .Treatment group was given oxaliplatin total dose of 50 -75 mg · m -2 , once a week , and capecitabine, twice a day, with the total dose of 1200-1550 mg· m-2.And 35 d a course , all patients were given three courses treatment.Clini-cal efficacy , improvement in quality of life and adverse drug reactions of the two groups were observed.Results After treatment, the objective response rate in treatment group (76.93%) was significantly higher than that in control group ( 42.31%, P<0.05 ); the quality of life in treat-ment group was significantly better than that in control group ( P<0.05 ).The incidence rate adverse reactions in treatment group were significantly lower than that in control group ( P<0.05 ).Conclusion Capecitabine combined with oxaliplatin for the treatment of patients with advanced colorectal cancer had a good clinical efficacy , low incidence of adversereactions , which can improve the quality of life.关键词
卡培他滨/奥沙利铂/晚期直肠癌/化学治疗Key words
capecitabine/oxaliplatin/advanced colorectal cancer/chemotherapy分类
医药卫生引用本文复制引用
黄新成,王玉斌,徐臣光,余新国,叶光..卡培他滨单药或联合奥沙利铂同步放化疗对晚期直肠癌的临床疗效研究[J].中国临床药理学杂志,2016,(2):129-131,3.基金项目
温州市科技计划基金资助项目 （）
