中国临床药理学杂志Issue(2)：138-140,3.DOI:10.13699/j.cnki.1001-6821.2016.02.014
甲氨蝶呤化疗常见不良反应的影响因素分析
Analysis of influence factors of the common adverse reactions after high -dose methotrexate chemotherapy
摘要
Abstract
Objective To evaluate the influence factors of common adverse reactions after high -dose methotrexate chemotherapy , and to provide basis for safe and rational clinical use of methotrexate.Methods Treatment protocols were referred to collaborative group of adults acute lymphoblastic leukemia ( CALLG2008 ) protocol, diagnosis and treatment of childhood acute lymphoblastic leukemia recommenda-tions, Hyper -CVAD protocol , improvement Bonn protocol , BFM90 protocol.Basic information , blood routine and biochemistry tests , metho-trexate plasma concentration , MTHFR C677 T gene polymorphism detec-tion results , and adverse reactions during the chemotherapy were collect-ed, and then analyzed the impact of fixed effect factors on adverse reac-tions by non -conditional Logistic regression.Results A total of 112 cases of patients with lymphatic cancer were recruited.Mucosal lesions , bone marrow suppression and anemia were mainly adverse reactions.Occurrence of oral mucositis was affected by patients ’ gender , weight and MTHFR gene type , while the incidence of anemia and bone marrow suppression after chemotherapy was affected by patients ’ weight and MTHFR gene type.Conclusion The impact factors of adverse reactions in chemotherapy of high -dose methotrexate were complicated , conducting relevant researches on influence factors of adverse reactions can provide foundation for individualized chemotherapy of high -dose methotrexate.关键词
血液系统恶性肿瘤/大剂量甲氨蝶呤/不良反应/影响因素/用药安全Key words
hematologic malignancy/high-dose methotrexate/adverse reaction/influence factor/medication safety分类
医药卫生引用本文复制引用
王轶睿,王捷,安琳娜,曹红,武云..甲氨蝶呤化疗常见不良反应的影响因素分析[J].中国临床药理学杂志,2016,(2):138-140,3.基金项目
新疆维吾尔自治区卫生厅青年科技人才专项基金资助项目 （）
