中国临床药理学杂志Issue(2)：163-165,3.DOI:10.13699/j.cnki.1001-6821.2016.02.022
赶黄草提取物对大鼠酒精性脂肪肝的影响
Effects of ethanol extract from Phethorum Chinese Pursh on the alcoholic fatty liver in rats
摘要
Abstract
Objective To compare alcoholic fatty liver effects of different volume fraction of ethanol extracts from Penthorum Chinese Pursh (EPCP) in rats.Methods Rat models of alcoholic fatty liver were in-duced by intragastric administration of alcohol and breeding provender with FeSO 4.Meanwhile , the rats were treated with tiopronin ( 50 mg· kg-1· d-1, for 4 weeks), different volume fraction (35%, 55%, 75%, 95%, 3 g· kg -1 · d -1 , 10 mL · kg -1 ) of ethanol EPCP for 4 weeks.The histopathological changes in the liver were determined.The serum levels of alanine aminotransferase ( ALT ) , aspartate aminotrans-ferase(AST),total cholesterol(TC), triglyceride(TG)and low-density and lipoprotein cholesterol ( LDL -C ) were determined.Results Rat models of alcoholic fatty liver were induced successfully after 6 weeks intragastric administration of alcoho 1.Compared to the model group , the steatosis states of liver in EPCP group were improved , while the serum TC, TG and LDL -C levels decreased significantly ( P <0.05, P<0.01).Compared to the 35%EPCP group, the serum AST, TC,TG and LDL -C levels of 75% and 95% ethanol EPCP group decreased significantly ( P <0.05 , P<0.01 ).Conclusion Both the different volume fraction of EPCP can prevent alcoholic fatty liver , the 75%,95%EPCP groups have better effect on alcoholic fatty liver.关键词
赶黄草/乙醇提取物/酒精性脂肪肝Key words
Penthorum Chinese Pursh/ethanol extract/alcoholic fatty liver分类
医药卫生引用本文复制引用
李国春,黄新武,尹加珍,邓谷霖,唐勇..赶黄草提取物对大鼠酒精性脂肪肝的影响[J].中国临床药理学杂志,2016,(2):163-165,3.基金项目
四川省科技厅课题基金资助项目 （）
