中国临床药理学杂志Issue(3)：195-197,201,4.DOI:10.13699/j.cnki.1001-6821.2016.03.001
脑梗死患者血清生物标志物水平与颈动脉斑块的相关性研究
Correlation of the level of serum biomarkers with carotid plaque in cerebral infarction patients
摘要
Abstract
Objective To investigate the association of the levels of serum oxidized low density lipoprotein ( ox -LDL ) , C -reactive protein ( CRP) and matrix metalloproteinase -9 ( MMP -9 ) of atherosclerotic cerebral in infarction patients with the carotid intima -media thickness ( IMT) and the stability of plaque.Methods A total of 110 patients with atherosclerotic cerebral infarction (ACI, group A),90 patients with lacunar infarction ( LACI, group B ) and 100 healthy volunteers ( group C) were selected.The levels of serum ox -LDL,CRP and MMP-9 by enzyme linked immunosorbent assay (ELISA) were detected and the IMT and the plaque formation were measured.Results The serum ox-LDL, CRP,MMP-9,IMT and the detection rate of group A and B were signifi-cantly higher than those of group C ( P<0.05 );serum ox-LDL, CRP, MMP-9 , smoking were the independent risk factors of the formation of carotid plaque in cerebral infarction patients ( P<0.05 ).The levels of serum ox -LDL, CRP, MMP -9 in the cerebral infarction patients without plaque group , with stable plaque group and unstable plaque group increased in turn ( P<0.05 ).Conclusion The increased levels of serum ox -LDL, CRP, MMP -9 in cerebral infarction patients are closely related with the bodiness of carotid artery IMT , the formation of the plaque and the stability.关键词
脑梗死/血清氧化低密度脂蛋白/C反应蛋白/颈动脉斑块/相关性/金属基质蛋白-9Key words
cerebral infarction/serum oxidized low density lipoprotein/c-reactive protein/carotid artery plaque/correlation/matrix metalloproteinase-9分类
医药卫生引用本文复制引用
宋爱霞,纪蓉,刘俊峰,薛茜..脑梗死患者血清生物标志物水平与颈动脉斑块的相关性研究[J].中国临床药理学杂志,2016,(3):195-197,201,4.基金项目
河北省卫计委医学科学研究重点课题计划基金资助项目（20150469）；河北省卫计委2014医学适用技术跟踪基金资助项目 （）
