中国临床药理学杂志Issue(3)：202-205,4.DOI:10.13699/j.cnki.1001-6821.2016.03.003
L 型钙离子通道α1C亚基基因多态性与钙通道阻滞药降压疗效的关系
Relationship of the calcium channel voltage-dependent L type, alpha 1C subunit gene polymorphism and efficacy of calcium channel blockers
摘要
Abstract
Objective To evaluated the association of calcium channel voltage-dependent L type ,alpha 1C subunit gene(CACNA1C) polymor-phism with the effectiveness of calcium channel blockers ( CCB ) therapy in endstage renal disease ( ESRD ) patients.Methods The distribution of CACNA1 C polymorphism 215 ESRD patients was investigated via the polymeras chain reaction and bidirectional sequencing.Multiple linear regression was used to association analysis between polymorphisms and efficacy of CCB.Results The CACNA1 C genotype distributions were in Hardy-Weinberg equilibrium.The patients with rs2238032 genotype who carried the GT allele had higher haemoglobin levels when compared to carriers of TT genotypes (117.53 ±20.89 ) vs (99.52 ±20.59 ) g· L-1 ( P<0.01).The patients with rs1051375 genotype who carried the AA allele had lower serume creatinine levels when compared to carriers of GA and GG genotypes ( 656.79 ±288.74 ) vs ( 937.8 ±295.15 ) vs (1113.2 ±433.44 ) μmol· L-1 ( P<0.01 ).Compared to carriers of TT and CC genotypes , CT genotypes had high trend of ΔDBP level ( P<0.05).Multivariate analysis of variance showed a significant effect of rs2238032 genotypes on the efficacy of CCB.The carriers with the TT genotype had a better treatment response to CCB compared to the GT carriers.Conclusion Our results suggest that the CACNA 1 C polymorphism may be associated with the efficacy of CCB therapy in ESRD patients.关键词
L型钙离子通道α1C基因/终末期肾脏病/钙通道阻滞药/基因多态性/临床药理Key words
calcium channel voltage -dependent L type , alpha 1C subunit gene/endstage renal disease/calcium channel blocker/gene polymorphism/clinical pharmacology分类
医药卫生引用本文复制引用
周君,陈菊..L 型钙离子通道α1C亚基基因多态性与钙通道阻滞药降压疗效的关系[J].中国临床药理学杂志,2016,(3):202-205,4.基金项目
海口市重点科技基金资助项目 （）
