中国临床药理学杂志Issue(3)：209-211,3.DOI:10.13699/j.cnki.1001-6821.2016.03.005
米非司酮联合甲氨蝶呤治疗异位妊娠的临床研究
Clinical effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy
张玲 1王鵷 1陈祥云1
作者信息
- 1. 上海市嘉定区南翔医院 妇产科，上海201802
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy and safety of mifepristone combined with methotrexate in the treatment of ectopic preg-nancy.Methods A total of 60 cases of ectopic pregnancy pregnant women were randomized divided into trial group and control group , 30 cases in each group.Trial group was treated with methotrexate 50 mg· m-2 , and mifepristone 100 mg, once a day;while the control group was treated with methotrexate 50 mg · m-2.The course of treatment was two weeks.The level of β-human chorionic gonadotrophin (HCG) value, recovery time , accessory mass piece diameter and adverse drug reactions were recorded and compared.Results After 2 weeks treatment , serumβ-HCG of all patients significantly decreased , the average diameter wrapped piece significantly decreased compared with that before treatment ( P<0.05 ) in two groups.The extent of trial group was significantly bet-ter than that of control group.Total effective rate of trial group was 92.5%, higher than that of control group 72.5%( P<0.05 ).The rate of adverse drug reactions with gastrointestinal in trail group was significantly lower than that of control group ( P<0.05 ).Conclusion Mifepristone combined methotrexate for ectopic pregnancy has better clinical efficacy and less adverse drug reactions than methotrexate alone.关键词
米非司酮/甲氨蝶呤/异位妊娠/临床疗效Key words
mifepristone/methotrexate/ectopic pregnancy/clinical effect分类
医药卫生引用本文复制引用
张玲,王鵷,陈祥云..米非司酮联合甲氨蝶呤治疗异位妊娠的临床研究[J].中国临床药理学杂志,2016,(3):209-211,3.
