中国临床药理学杂志Issue(3)：215-217,3.DOI:10.13699/j.cnki.1001-6821.2016.03.007
转运体基因多态性对癫痫患者丙戊酸血药浓度及临床疗效的影响
Influence of transporter genetic polymorphisms on valproic acid blood concentration and clinical efficacy of epilepsy patients
摘要
Abstract
Objective To investigate the effect of ABCC2, MCT1, MCT2, OATP2B1 on valproic acid ( VPA) blood concentration and effi-cacy in epilepsy patients.Methods One hundred sixty epilepsy patients receiving VPA as monotherapy were included.Steady-state blood con-centration of VPA was measured by a high -performance liquid chroma-tography method.ABCC2 rs2273697 , rs3740066 , MCT1 rs60844753 , rs7169, MCT2 rs10784000 , rs10877333 , rs1693614 , OATP2B1 rs2306168 genotypes were detected by Sequenom Mass ARRAY ® sys-tem.The association between different genotypes and VPA concentration was analyzed by Kruskal -Wallis test.Efficacy comparison among geno-types were performed by Chi -square test.Results The concentration of valproic acid in ABCC2 rs2273697 AA genotype was considerably higher than the GA and GG genotypes ( P <0.05 ).There was no significant effect of other SNPs on VPA dose -adjusted concentration and clinical efficacy.Conclusion ABCC2 rs2273697 polymorphism is associated with valproic acid blood concentrations , and further studies are needed to verify the effect of this SNP on VPA blood concentration and clinical efficacy.关键词
丙戊酸/转运体/基因多态性/血药浓度/临床疗效Key words
valproic acid/transporter/polymorphism/blood concentra-tion/clinical efficacy分类
医药卫生引用本文复制引用
陈娟,王雪丁,周列民,李宏亮,周亚芳,秦家明,戴启麟,黄民..转运体基因多态性对癫痫患者丙戊酸血药浓度及临床疗效的影响[J].中国临床药理学杂志,2016,(3):215-217,3.基金项目
“十二五”国家科技重大专项资金资助项目（2012ZX09506001－004）；国家自然科学基金资助项目 （）
