摘要
Abstract
Objective To investigate the clinical effect of glucocorticoid combined with gamma globulin in the treatment of idiopathic thrombocyto-penic purpura.Methods Forty children with idiopathic thrombocytope-nic purpura were divided into treatment group and control group , 20 ca-ses in each group.Control group was firstly intravenous given methyl-prednisolone 5 -8 mg · kg -1 · d-1 , then received oral prednisone 2 mg· kg -1 · d-1.On the basis of control group , the treatment group was intravenous given immunoglobulin 400 mg· kg -1 · d-1.All patients were treated for 1 month , and followed up for 3 months.The clinical effi-ciency , platelet began to rise time and platelet peak time of the two groups were observed.Results The effective rate and total efficiency of treatment group were 90.0%, 95.0%, significantly higher than those of control group , which were 66.7%, 85.0% ( P<0.05 ).The platelet began to rise time and platelet peak time in treatment group were (3.4 ±1.6), (8.1 ±3.1) d, significantly shorter than those in control group, which were (5.0 ±1.8), (12.9 ±5.1) d (P<0.05).After 3 months follow -up, the recurrence rate in treatment group and control group were 0, 46.2%, with significant difference ( P <0.01 ) .Conclusion Glucocorticoid combined with gamma globulin in the treat-ment of idiopathic thrombocytopenic purpura was markedly effective.关键词
糖皮质激素/丙球蛋白/特发性血小板减少性紫癜/临床疗效Key words
glucocorticoid/gamma globulin/idiopathic thrombocytopenic purpura/clinical effect分类
医药卫生
