中国临床药理学杂志Issue(3)：221-223,3.DOI:10.13699/j.cnki.1001-6821.2016.03.009
苦参碱注射液联合化疗对急性髓系白血病中miR－125 b表达的影响
Effect of Matrine injection combined with chemotherapy on the miR -125 b expression in acute myeloid leukemia
摘要
Abstract
Objective To study the effect of Matrine injection combined with chemotherapy on the miR-125 b expression in acute myeloid leuke-mia.Methods During March 2013 to February 2015 , 76 patients with acute myeloid leukemia from our hospital were involved and then it divi-ded into trial group ( n=38 ) and control group ( n=38 ) according to a random number table.Patients in control group were received erythromy-cin +cytarabine chemotherapy treatment .Patients in trial group were given Matrine 20 mL on this basis of control group .All patients were taken two treatment courses ( 2 weeks ).Karnofsky score , the expression levels of miR-125 of patients before and after treatment were compared between two groups.The clinical efficacy of the two groups and adverse reactions were observed.Results After treatment, total efficiency (86.84%) of the trial group was higher than that of control group ( 60.53%) , the difference was statistically significant ( P <0.05 ).Karnofsky score of patients in the trial group (83.23 ±14.35 ) points was significantly higher than that of control group (77.22 ±11.31 ) points, the difference was statistically significant ( P <0.05 ).MiR -125 b expression of patients in the trial group ( 5.02 ± 0.75 ) was significantly lower than that of control group (11.42 ±1.44 ) , with a statistically significant difference ( P<0.05 ).The drugs adverse reactions of leukocyte re-duced rate (2.63%), erythrocyte lower rate (2.63%), hepatic dysfunction rate (2.63%), oral mucositis, gastroin-testinal of patients in trial group were significantly lower than those of control group , the difference was statistically sig-nificant ( P<0.05 ).Conclusion Matrine injection combined with chemotherapy can significantly reduce the miR-125 b expression in patients with acute myeloid leukemia.关键词
苦参碱注射液/化疗/急性髓系白血病/miR-125 b表达Key words
Matrine/chemotherapy/acute myeloid leukemia/miR-125 b expression分类
医药卫生引用本文复制引用
黄伟萍,王世俊..苦参碱注射液联合化疗对急性髓系白血病中miR－125 b表达的影响[J].中国临床药理学杂志,2016,(3):221-223,3.基金项目
余姚市科技计划基金资助项目 （）
