中国临床药理学杂志Issue(3)：261-263,3.DOI:10.13699/j.cnki.1001-6821.2016.03.021
伏立康唑在不同年龄段使用中安全性和有效性以及药代动力学差异的系统评价
Difference of efficacy, safety and pharmacokinetics of voriconazole in different age:A systematic review
郭一萌 1安琳娜 2陈恳 3张弨1
作者信息
- 1. 北京大学 第三医院 药剂科，北京 100191
- 2. 山西省肿瘤医院 药学部，太原 030013
- 3. 新疆医科大学 第一附属医院 药剂科，乌鲁木齐830054
- 折叠
摘要
Abstract
Objective To evaluate the difference of efficacy , safety and pharmacokinetics of voriconazole between paediatric and adult patients.Methods The databases of PubMed , EmBase , Coehrane Controlled Trials Register, CNKI, CBM, WanFang Database and Clinical Trials were retrieved from database establish time to March 2015.Data were ana-lyzed using RevMan 5.1 software.Results A total of 9 studies (n=314) were included.The results of Meta-analysis showed there was no statis-tical differences between pediatric and adults patients for the effective rate of treating infection, the success rate of target Ctrough, the incidence of liver toxicity , the incidence of abnormal visual , the incidence of neu-rotoxicity, AUC/Dose( iv) and Ctrough ( po) ( P >0.05 ).But significant difference was found in AUC/Dose(po),Cmax/Dose(iv),Cmax/Dose(po) and Ctrough ( iv) ( P<0.05 ).Conclusion The current evidence shows that after the paediatric patients taking the voriconazole , the efficacy and safety were similar or less than the teenages and adults , and the pharma-cokinetic difference between paediatric and adult was obvious.关键词
伏立康唑/儿童/安全性/有效性/系统评价Key words
voriconazole/paediatric/safety/effectiveness/systematic review分类
医药卫生引用本文复制引用
郭一萌,安琳娜,陈恳,张弨..伏立康唑在不同年龄段使用中安全性和有效性以及药代动力学差异的系统评价[J].中国临床药理学杂志,2016,(3):261-263,3.
