中国临床药理学杂志Issue(4)：294-296,3.DOI:10.13699/j.cnki.1001-6821.2016.04.002
阿魏酸哌嗪联合厄贝沙坦治疗糖尿病肾病的临床疗效及安全性评价
Clinical efficacy and safety of piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy.Methods A total of 74 patients with diabetic nephropathy were randomly divided into treatment group ( n=37 ) and control group (n=37).Control group was received irbesartan 150 mg, once a day.Treatment group was given piperazine ferulate 150 mg, once a day on the basis of control group.The treatment course of two groups was 12 weeks.The clinical efficacy , serum creatinine , blood glucose , blood urea nitrogen, urinary albumin excretion rate , hemodynamic level and adverse drug reactions were compared between two groups.Results After treat-ment, total effective rate in treatment group was significantly higher than that in control group (94.59%vs 75.68%, P<0.05).After treatment, serum creatinine , urinary albumin excretion rate , hemodynamic level in treatment group were significantly better than those of control group ( P<0.05).The blood glucose and blood urea nitrogen in two group were no obvious change ( P>0.05 ).Patients in two groups showed dif-ferent degrees of nausea , vomiting, abdominal pain , dizziness and other symptoms , but after symptomatic treatment turn , they were got better.There were no statistical significance of the incidence of adverse drug reactions between two groups ( P>0.05 ).Conclusion Piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy patients was effective , which can improve the renal hemodynamics , protect the renal function , and reduce the proteinuria.关键词
阿魏酸哌嗪/厄贝沙坦/糖尿病肾病/肾功能/临床疗效/安全性Key words
piperazine ferulate/irbesartan/diabetic nephropathy/renal function/clinical efficacy/safety分类
医药卫生引用本文复制引用
魏冬红,赵桂东,余敏,江蓓..阿魏酸哌嗪联合厄贝沙坦治疗糖尿病肾病的临床疗效及安全性评价[J].中国临床药理学杂志,2016,(4):294-296,3.基金项目
2014年山东省自然科学基金资助项目 （）
