中国临床药理学杂志Issue(4)：300-302,3.DOI:10.13699/j.cnki.1001-6821.2016.04.004
氯沙坦钾对老年原发性高血压伴高尿酸血症的临床疗效及安全性评价
Clinical efficacy and safety of losartan potassium in the treatment of aged patients with essential hypertension and hyperuricemia
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of domestic produced losartan potassium in aged patients with essential hypertension and hyperuricemia.Methods Eighty patients diagnosed with hypertension with hyperuricemia were randomly divided into treat-ment group ( n=40 ) and control group ( n=40 ).Patients in treatment group were given losartan potassium 50 mg· d -1 , and patients in control group given candesartan 4 mg · d-1.The treatment lasted for 8 weeks.Clinical efficiency , serum uric acid levels and blood pressure of the two groups were measured after treatment.Results After treatment , the total effective rate was equal 95.0%in treatment group and control group and the markedly effective rate were 55.0% and 57.5% respectively (P>0.05).After treatment, the reduction of systolic blood pressure ( SBP ) and diastolic blood pressure ( DBP ) were ( 19.65 ±12.23 )/( 11.80 ±8.21 ) mmHg vs ( 24.78 ±15.38 )/( 13.93 ±10.60 ) mmHg in treatment group and control group ( P<0.05 ) , there was no significant difference between the two groups ( P>0.05 ).After treatment , the level of uric acid decreased apparently in treatment group was (435.04 ±53.57 )μmol L-1 , and (483.68 ±63.50 ) μmol· L-1 in control group and treatment group was significantly lower than control group and before treatment ( P<0.05 ).There was no adverse reaction in treatment group , 1 case in control group ( 2.5%) .There was no significant change in heart rate in two groups before and after treatment.Conclusion Domes-tic produced losartan potassium was proved to be a stable and effective antihypertensive medication with little adverse drug reactions.关键词
氯沙坦钾/坎地沙坦酯/原发性高血压/老年/高尿酸血症Key words
losartan potassium/candesartan/essential hypertension/aged people/hyperuricemia分类
医药卫生引用本文复制引用
杨霈龙,王立新,袁芳..氯沙坦钾对老年原发性高血压伴高尿酸血症的临床疗效及安全性评价[J].中国临床药理学杂志,2016,(4):300-302,3.基金项目
河北省科技计划基金资助项目（142777111D）；河北北方学院自然科学研究计划基金资助项目（ZD201415）；国家“十二·五”科技支撑基金资助项目（2011BAI11B04）；河北省卫生厅科研基金资助项目 （）
