中国临床药理学杂志Issue(4)：309-311,326,4.DOI:10.13699/j.cnki.1001-6821.2016.04.007
磷酸二甲啡烷治疗干性咳嗽的临床疗效及安全性评价
Evaluation of clinical curative effect and safety of dimemorfan phosphate in the treatment of dry cough
陈燕文 1梅晓东 2赖克方 3秦志强 4刘跃建 5金发光 6曹照龙 1唐飞 1崔可鑫 1穆新林 1刘双 7王浩彦 8韩晓雯 9李惠萍10
作者信息
- 1. 北京大学 人民医院 呼吸与危重症科，北京100044
- 2. 安徽省立医院呼吸内科，合肥 230001
- 3. 广州医学院第一附属医院呼吸内科，广州 510120
- 4. 广西壮族自治区人民医院呼吸内科，南宁 530021
- 5. 四川省人民医院呼吸内科，成都 610072
- 6. 第四军医大学第二附属医院呼吸内科，西安 710038
- 7. 首都医科大学 附属安贞医院 呼吸内科，北京 100029
- 8. 首都医科大学附属友谊医院呼吸内科，北京 100050
- 9. 河北省人民医院呼吸内科，石家庄 050051
- 10. 上海肺科医院呼吸内科，上海201209
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of dimemorfan phosphate in the treatment of dry cough.Methods Three hundred seventy -eight patients with dry cough were randomly divided into experimental group ( n=216 ) , positive control ( n=108 ) and place-bo group ( n=54 ).Experimental group was taken dimemorfan phosphate 20 mg, orally, tid, 5 -7 d.Positive control group was taken dextro-methorphan 30 mg, orally, tid, 5 -7 d.Placebo group was taken dimemorfan phosphate simulation tablets 20 mg or dextromethorphan simulation tablets 30 mg, tid, 5-7 d.Comparison of the clinical effica-cy, change of the total cough score after 5-7 d treatment, and the inci-dence of adverse drug reactions between the three groups.Results The clinical effectiveness of cough symptom after treatment , experimental group and positive control group and placebo group were 81.02%, 84.26%and 38.89%, respectively.The difference between experimen-tal group with placebo group was statistically significant ( P <0.01 ) , there was no statistically significant difference between experimental group with positive control group ( P>0.05 ).The average decrease of total cough score after treatment in the experimental group , the positive control group and the placebo group were (2.34 ±1.42), (2.43 ±1.55) and (1.39 ±1.20), respectively.The decrease in the total cough score of experimen-tal group was superior to that of placebo group ( P<0.01 ) , the decrease in the total cough score of experimental group was not inferior to positive control group ( P>0.05 ).The incidence of adverse events were 4.21% in experimental group , 12.04%in positive control group and 5.66%in placebo group , respectively.Among these , the incidence of adverse events associated with drug were 1.87%, 10.19%, 5.66%, respectively.Conclusion Dimemorfan phos-phate has exact antitussive efficacy in the treatment of dry cough , has the same antitussive efficacy and similar side effect in the treatment of dry cough compared with the dextromethorphan.关键词
磷酸二甲啡烷/右美沙芬/安慰剂/干性咳嗽/临床疗效/安全性Key words
dimemorfan phosphate/dextromethorphan/placebo/dry cough/clinical efficacy/safety分类
医药卫生引用本文复制引用
陈燕文,梅晓东,赖克方,秦志强,刘跃建,金发光,曹照龙,唐飞,崔可鑫,穆新林,刘双,王浩彦,韩晓雯,李惠萍..磷酸二甲啡烷治疗干性咳嗽的临床疗效及安全性评价[J].中国临床药理学杂志,2016,(4):309-311,326,4.
