中国临床药理学杂志Issue(4)：318-320,3.DOI:10.13699/j.cnki.1001-6821.2016.04.010
血清生物标志物水平与脑梗死伴颈动脉斑块形成的关系
Relationship between the serum biomarkers levels and the carotid artery plaque in atherosclerotic cerebral infarction patients
摘要
Abstract
Objective To investigate the association of the levels of serum oxidized low density lipoprotein ( ox-LDL), C-reactive protein (CRP) and matrix metalloproteinase -9(MMP-9) with carotid artery plaque in atherosclerotic cerebral infarction patients.Methods One hundred -ten patients with atherosclerotic cerebral infarction ( ACI ) selected as the observation group , and 100 healthy subjects as control group were selected to detect the level of serum ox -LDL, CRP and MMP-9 by enzyme-linked immunosorbent assay and the ACI patients were measured by carotid artery ultrasound.Results The levels of serum ox-LDL, CRP, and MMP-9 in observation group were higher than those in control group [ ( 261.54 ±24.51 ) vs ( 146.51 ±19.59 )μg· mL-1;(4.54 ±1.21) vs (0.87 ±0.15) μg· mL-1;(139.76 ±41.22) vs (65.76 ±23.48 ) ng· mL-1 , and there was significantly different ( all P<0.01 ).The levels of serum ox -LDL, CRP, and MMP-9 in ACI patients with plaque were higher than those in ACI patients without plaque [(205.27 ±20.11) vs (162.50 ±19.71)μg· mL-1;(4.32 ±1.03) vs (1.21 ±0.10 ) μg· mL-1;(90.71 ±24.03 ) vs (71.71 ±23.21 ) ng· mL -1 , and there was significantly different ( P<0.01 ).Serum ox-LDL, CRP and MMP-9 levels were the independent risk factors for the formation of carotid plaques of ACI patients , and had significantly positive correlation.Conclusion The high level of serum ox -LDL, CRP, and MMP-9 are the independent risk factors for carotid plaques of ACI , which could be used as important reference indexes for diagnosis of the formation of carotid artery plaque on ACI patients.关键词
血清氧化低密度脂蛋白/C反应蛋白/金属基质蛋白-9/颈动脉斑块形成Key words
serum oxidized low density lipoprotein/C-reactive protein/matrix metalloproteinase -9/carotid artery plaque分类
医药卫生引用本文复制引用
宋爱霞,宋征宇,纪蓉,薛茜..血清生物标志物水平与脑梗死伴颈动脉斑块形成的关系[J].中国临床药理学杂志,2016,(4):318-320,3.基金项目
河北省卫计委医学科学研究重点课题计划基金资助项目 （）
